Biological Activity
ave 0991 is an agonist of angiotensin-(1-7) receptor [1].as an ang-(1–7) mimic, ave0991 acts as a nonpeptide agonist of angiotensin-(1-7) receptor. in water-loaded mice (c57bl/6), ave0991(0.58 nmol/g)produces a significant decrease of water dieresis. the antidiuretic effect of ave was associated with an increase in urine osmolality. it also occurs in water-loaded swiss mice. the antidiuretic action of ave can be blocked by the ang ii antagonists completely, demonstrating the specificity of ave 0991. since ang ii promotes atherogenesis and ang-(1–7) opposites ang ii action, it is reported that ave 0991 can inhibit atherogenesis in apolipoprotein e (apoe)-knockout mice model [1, 2].
References
[1] sergio veloso brant pinheiro, ana cristina simoes e silva, walkyria oliveira sampaio, renata dutra de paula, elizabeth pereira mendes, elizabete dias bontempo, joao bosco pesquero, thomas walther, natalia alenina, michael bader, markus bleich, robson augusto souza santos. nonpeptide ave 0991 is an angiotensin-(1–7) receptor mas agonist in the mouse kidney. hypertension. 2004, 44: 490-496.
[2] j. toton-zuranska, m. gajda, g. pyka-fosciak, k. kus, m. pawlowska, a. niepsuj, p. wolkow, r. olszanecki, j. jawien, r. korbut. ave 0991- angiotensin-(1-7) receptor agonist, inhibits atherogenesis in apoe-knockout mice. journal of physiology and pharmacology. 2010, 61(2):181-183.
