b-AP15
- Product Nameb-AP15
- CAS330450-45-8
- CBNumberCB02667632
- MFC22H17N3O6
- MW419.39
- MDL NumberMFCD25976718
- MOL File330450-45-8.mol
Chemical Properties
Boiling point | 670.4±55.0 °C(Predicted) |
Density | 1.416±0.06 g/cm3(Predicted) |
pka | -1.39±0.20(Predicted) |
b-AP15 Chemical Properties,Usage,Production
Enzyme inhibitor
This deubiquitinase inhibitor (FW = 421.31 g/mol; CAS 1009817-63-3), also named 3,5-bis[ (4-nitrophenyl) methylene]-1- (1-oxo-2-propen-1-yl) - (3E,5E) -4-piperidinone, targets two proteasome-associated ubiquitin carboxyl-terminal hydrolase-14, or USP14, and Ubiquitin Carboxyl-terminal Hydrolase isozyme L5 UCHL5, IC50 = 2.1 μM, resulting in a rapid accumulation of high-molecular-weight ubiquitin conjugates and functional shutdown of proteasome. Interestingly, b-AP15 displays several differences with respect to bortezomib including insensitivity to over-expression of the anti-apoptotic mediator Bcl-2 and anti-tumor activity in solid tumor models. Inhibition of DUBs blocked the processing and release of interleukin IL-1β in both mouse and human macrophages. DUB activity was necessary for inflammasome association as DUB inhibition also impaired ASC oligomerization and caspase-1 activation without directly blocking caspase- 1 activity. These data reveal the requirement for DUB activity in a key reaction of the innate immune response and highlight the therapeutic potential of DUB inhibitors for chronic auto-inflammatory diseases. (See also Bortezomib, Eeeyarestatin I)Preparation Products And Raw materials
b-AP15 Suppliers
Global(55)Suppliers
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
021-58955995 | sales@medchemexpress.cn | United States | 4863 | 58 | |
eric_feng1954@126.com | China | 9254 | 55 | ||
15076683720 | klq@cw-bio.com | China | 3444 | 55 | |
0550-5196001 15000891977 |
wj520wjxby@126.com | China | 1832 | 55 | |
021-61998551 13122364865 |
sale1@shzysw.net | China | 9763 | 58 | |
15342225168 | yutianchun2007@126.com | China | 9964 | 58 | |
15527250409 | wenhaotian12@163.com | China | 4576 | 58 | |
021-58432009 400-005-6266 |
marketing@energy-chemical.com | China | 44941 | 58 | |
17771424646 | shoubull@126.com | China | 965 | 58 | |
18601717983 | guojing@bioleaper.com | China | 5615 | 58 |
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