Chemical Properties
yellow crystalline powder
Uses
Reactant for preparation of:
- Protein kinase inhibitors
- Potential fructose 1,6-bisphosphatase inhibitors
- Factor Xa inhibitors
- Antagonist of the mineralocorticoid receptor
- Antitumor sulfonamides
- Inosine monophosphate dehydrogenase (IMPDH) inhibitors
- Subtype-selective cyclooxygenase (COX) inhibitors
- Thrombin protease-activated receptor (PAR-1) ligands
Uses
7-Nitroindole is a useful reactant for the preparation of various compounds and inhibitors.
Uses
7-Nitroindole is a reagent used in chemical synthesis. It has been used in the synthesis of protein kinase and inosine monophosphate inhibitors, beta3 agonists and CCK-1 receptor modulators. 7-Nitroindole has also been used as a photochemical precursor of the 2'-deoxyribonolactone analog.
Application
Reactant for preparation of:
Protein kinase inhibitors
Potential fructose 1,6-bisphosphatase inhibitors
Factor Xa inhibitors
Antagonist of the mineralocorticoid receptor
Antitumor sulfonamides
Inosine monophosphate dehydrogenase (IMPDH) inhibitors
Subtype-selective cyclooxygenase (COX) inhibitors
Thrombin protease-activated receptor (PAR-1) ligands
Synthesis Reference(s)
Canadian Journal of Chemistry, 42, p. 1235, 1964
DOI: 10.1139/v64-189
