14,15-LEUKOTRIENE C4

Description

Leukotrienes (LTs) are a group of acute inflammatory mediators derived from arachidonic acid in leukocytes. The majority of these metabolites are formed through the 5-lipoxygenase (5-LO) pathway. 14,15-LTC₄ is a member of an alternate class of LTs synthesized by a pathway involving the dual actions of 15- and 12-LOs on arachidonic acid via 15-HpETE and 14,15-LTA₄ intermediates. 14,15-LTC₄ is classified as an eoxin, because it is formed mostly by eosinophils. However, mast cells and nasal polyps can synthesize 14,15-LTC₄ as well. Little is known about the physiological actions of 14,15-LTC₄. It has weak contractile activity on both guinea pig ileum and pulmonary parenchyma in contrast to the effects of 5-LO-derived LTs. However, in an in vitro permeability assay, 14,15-LTC₄ can increase vascular permeability of human endothelial cell monolayers, with similar potency to that of 5-LO-derived LTs resulting in plasma leakage - a hallmark of inflammation.

Uses

14,15-Leukotriene C4 is an acute inflammatory mediator.

References

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[5] SAILESH S. Sheep Uterus Dual Lipoxygenase in the Synthesis of 14,15-Leukotrienes[J]. Archives of biochemistry and biophysics, 1994, 315 2: Pages 362-368. DOI: 10.1006/abbi.1994.1512
[6] J M DRAZEN. Contractile activities of structural analogs of leukotrienes C and D: necessity of a hydrophobic region.[J]. Proceedings of the National Academy of Sciences of the United States of America, 1981, 78 5: 3195-3198. DOI: 10.1073/pnas.78.5.3195
[7] A SALA. Contractile and binding activities of structural analogues of LTC4 in the longitudinal muscle of guinea-pig ileum.[J]. Eicosanoids, 1990, 3 2: 105-110.