Description
2,4-
Diamino-
6-
hydroxypyrimidine (DAHP) is a selective, specific inhibitor of GTP cyclohydrolase I, the rate limiting step for
de novo pterin synthesis. In HUVEC cells, the IC
50 for inhibition of BH
4 biosynthesis is about 0.3 mM. DAHP can be used to effectively block NO production in several cell types.
Chemical Properties
White Solid
Uses
2,4-Diamino-6-hydroxypyrimidine (DAHP) is a selective, specific inhibitor of GTP cyclohydrolase I, the rate limiting step for de novo pterin synthesis. In HUVEC cells, the IC50 for inhibition of BH4 biosynthesis is about 0.3 mM. DAHP can be used to effectively block NO production in several cell types.[Cayman Chemical]
Uses
It stands at the beginning of the enzyme-catalyzed cascade that starts with this seven-carbon carbohydrate and ends with the aromatic amino acids phenylalanine, tyrosine, and tryptophan
Uses
2,4-Diamino-6-hydroxypyrimidine (cas# 56-06-4) is a compound useful in organic synthesis.
Purification Methods
It recrystallises from H2O. [Beilstein 25 III/IV 3642.]
