Uses
C3a (70-77) is an octapeptide corresponding to the COOH terminus of C3a, exhibits the specificity and 1 to 2% biologic activities of C3a.
Biological Activity
C3a (70-77) is an octapeptide corresponding to the COOH terminus of C3a and exhibits C3a specificity and 1 to 2% biological activity.
in vitro
The direct interaction of C3a(70-77) with human mononuclear leukocytes in culture results in a concentration-dependent inhibition of the generation of LIF evoked by mitogens and by the antigen SK-SD.
References
[1] Payan DG, et al. Modulation of human lymphocyte function by C3a and C3a(70-77). J Exp Med. 1982 Sep 1;156(3):756-65. DOI:
10.1084/jem.156.3.756[2] Caporale LH, et al. The active site of C3a anaphylatoxin. J Biol Chem. 1980 Nov 25;255(22):10758-63. PMID:6968751
