Uses
Anti-Human IgG (Fc specific) antibody produced in rabbit has been used as a control in cysteine-rich angiogenic inducer 61 (CYR61) blocking experiment.
Uses
Monoclonal Anti-Human IgG (Fc specific) antibody produced in mouse has been used in:
- enzyme linked immunosorbent assay (ELISA)
- imprint immunofixation (IIF)
- immunofluorometric assay (IFMA)
- hemagglutination (HA)
- hemagglutination inhibition (HAI)
- particle counting immunoassay(PACIA)
Uses
Anti-Human IgG (Fc specific) antibody produced in goat has been used:
- in double-capture ELISA to measure antiglobulin responses in serum of transplant patients treated with CD52 monoclonal antibodies (CAMPATH-1G)
- in detection of IgG levels rheumatoid arthritis patients
- in small intestine biopsies
- in patients with acute myocardial infarction by immunoblotting
General Description
Immunoglobulin G (IgG), a widely expressed serum antibody, has two heavy chains and two light chains connected by a disulfide bond. It is a glycoprotein, usually found as a monomer. IgG is further subdivided into four classes namely, IgG1, IgG2, IgG3, and IgG4. IgG antibody subtype is the most abundant of serum immunoglobulins of the immune system. About 70 % of the total immunoglobulin consists of IgG.
Biochem/physiol Actions
IgG stimulates the classical pathway of the complement system. It neutralizes virus particles and toxins. IgG plays a crucial role in antibody-dependent cell-mediated cytotoxicity (ADCC). IgG might be associated with allergy. It has the longest serum half life.
