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Olopatadine hydrochloride

Olopatadine hydrochloride Structure
Olopatadine hydrochloride
  • CAS No.140462-76-6
  • Chemical Name:Olopatadine hydrochloride
  • CBNumber:CB0144403
  • Molecular Formula:C21H24ClNO3
  • Formula Weight:373.87316
  • MOL File:140462-76-6.mol
Olopatadine hydrochloride Property
  • Melting point: :242-245?C
  • storage temp.  :Refrigerator
  • solubility  :H2O: ≥20mg/mL
  • form  :solid
  • Merck  :14,6840
  • InChIKey :HVRLZEKDTUEKQH-NOILCQHBSA-N
  • CAS DataBase Reference :140462-76-6(CAS DataBase Reference)
  • FDA UNII :2XG66W44KF
Safety
  • Hazard Codes  :T,N
  • Risk Statements  :25-50
  • Safety Statements  :45-61
  • RIDADR  :UN 2811 6.1 / PGIII
  • WGK Germany  :3
  • RTECS  :HQ4135060
  • HS Code  :29329990
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal wordDanger
  • Hazard statements H301-H400
  • Precautionary statements P273-P301+P310
Olopatadine hydrochloride Price More Price(8)
  • Brand: Sigma-Aldrich
  • Product number: O0391
  • Product name : Olopatadine hydrochloride
  • Purity: ≥98% (HPLC)
  • Packaging: 10mg
  • Price: $69.5
  • Updated: 2020/08/18
  • Buy: Buy
  • Brand: Sigma-Aldrich
  • Product number: 1478403
  • Product name : Olopatadine hydrochloride
  • Purity: United States Pharmacopeia (USP) Reference Standard
  • Packaging: 150mg
  • Price: $500
  • Updated: 2020/08/18
  • Buy: Buy
  • Brand: TCI Chemical
  • Product number: O0361
  • Product name : Olopatadine Hydrochloride
  • Purity: >98.0%(HPLC)(T)
  • Packaging: 1g
  • Price: $255
  • Updated: 2020/06/24
  • Buy: Buy
  • Brand: Cayman Chemical
  • Product number: 11999
  • Product name : Olopatadine (hydrochloride)
  • Purity: ≥98%
  • Packaging: 10mg
  • Price: $29
  • Updated: 2020/06/24
  • Buy: Buy
  • Brand: Cayman Chemical
  • Product number: 11999
  • Product name : Olopatadine (hydrochloride)
  • Purity: ≥98%
  • Packaging: 25mg
  • Price: $65
  • Updated: 2020/06/24
  • Buy: Buy

Olopatadine hydrochloride Chemical Properties,Usage,Production

  • Description Patanol was launched in the US for use in allergic conjunctivitis. It can be prepared in five steps from the sodium salt of phydroxyphenylacetic acid methyl ester with phthalide. It has a fast onset of action with a long duration of action (due to slow dissociation kinetics) that combines the ability to prevent human conjunctival mast cell mediator release with selective H1-receptor antangonistic activity (greater H3:H1 selectivity than H2:H1 selectivity). In addition, Patanol had no inhibition of 5- lipoxygenase, PAF acetyltransferase and thromboxane synthase while interfering with phospholipase A2. It has a presynaptic inhibition of tachykinin release and inhibits bronchial sensory nerves through activation of small conductance calcium activated potassium channels. It was more potent than ketotifen and terfenadine and was effective at inhibition of PAF, LTC4 induced conjunctivitis and TXB2 production. It does not accumulate in the CNS, has a low affinity for H1-receptors in the brain, and significantly inhibits allergen induce sneezing. Patanol was more effective in conjuctival than in corneal or the trabecuiar meshwork cells.
  • Chemical Properties White Solid
  • Originator Kyowa Hakko (Japan)
  • Uses Dual acting histamine H1-receptor antagonist and mast cell stabilizer. Antiallergic; antihistaminic.
  • Uses antiallergic, antihistaminic;histamine H1 antagonist
  • Uses urinary antispasmodic
  • Uses Olopatadine hydrochloride is a potent, selective antagonist of the H1 histamine receptor (Ki = 16-41.1 nM), with much lower affinities for the H2 and H3 receptors (Ki = 43.4 and 172 μM, respectively). It blocks histamine-induced phosphoinositide turnover in isolated cells (IC50 = 9.5-39.9 nM) and prevents passive cutaneous anaphylaxis in rats (ED50 = 49 μg/kg) and anaphylactic bronchoconstriction in guinea pigs (ID50 = 30 μg/kg). Olopatadine is effective in treating allergic rhinitis and conjunctivitis. It also suppresses itch in patients with well-controlled chronic urticaria. In humans, this antihistamine does not cause cognitive or psychomotor impairment at therapeutic doses.[Cayman Chemical]
  • brand name Patanol (Alcon).
  • Veterinary Drugs and Treatments Olopatadine HCl is a selective H1 receptor antagonist and inhibitor of histamine release from mast cells. It is marketed for topical use to alleviate symptoms of allergic conjunctivitis in humans and is thought to be safe for use in children three years of age and older. Olopatadine, upon topical application in humans, was shown to have very limited systemic absorption. It was detectable in the milk of nursing rats, after topical application, and like most medications should be avoided in pregnant or nursing animals.
Olopatadine hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
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  • OlopatadineHydrochloride&gt
  • 140462-76-6
  • C21H23NO3ClH
  • C21H23NO3HCl
  • API
  • Opatanol, Pataday, Patanase, Allelock
  • APIs
  • Olopatadine
  • Amines
  • Heterocycles
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
  • Pharmaceutical material and intermeidates