Description
3-Propylxanthine is a xanthine derivative that antagonizes adenosine receptors (K
is = 44, 32, and 6.3 μM for A
1, A
2A, and A
2B, respectively) and cAMP phosphodiesterase (K
i = 42 μM). Through these actions, 3-propylxanthine induces smooth muscle relaxation, blocks smooth muscle contraction and VEGF secretion driven by adenosine receptor agonists, and reduces bronchial hyperresponsiveness.
Definition
ChEBI: Xanthine bearing a propyl substituent at position 3. A bronchodilator, it is used for the symptomatic treatment of asthma and chronic obstructive pulmonary disease, and in the management of cerebrovascular insufficiency, sickle cell disease, and diabetic n
uropathy.
