GUANIDINYL NALTRINDOLE

GUANIDINYL NALTRINDOLE Chemische Eigenschaften,Einsatz,Produktion Methoden

• Verwenden

  5′-Guanidinonaltrindole di(trifluoroacetate) Salt is a selective opioid receptor antagonist. It has also been utilized to develop fluorescent methods to identify phosphopantetheinyl transferase inhibitors.

• Verwenden

  5′-Guanidinonaltrindole di(trifluoroacetate) salt hydrate (GNTI) has been used as a selective κ opioid receptor antagonist:
  
  • to study the influence of opioid receptor types on the anti-hyperalgesic effect of dipeptidyl peptidase 4 (DPP4) inhibitors in inflammation
  • to study the role of κ opioid receptor in the forebrain-dependent associative task, Whisker-Trace Eyeblink conditioning (WTEB)
  • to validate its inhibitory actions on Akt kinase activities
  
  

• Biochem/physiol Actions

  5′-Guanidinonaltrindole di(trifluoroacetate) (GNTI) is a 5‘-guanidine derivative and a selective κ opiate receptor antagonist. It is five-fold more potent and 500-fold more selective than norbinaltorphimine (nor-BNI) for the κ opioid receptor in smooth muscle preparations.

GUANIDINYL NALTRINDOLE Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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