Aliskiren

Bezeichnung:Aliskiren

CAS-Nr173334-57-1

Englisch Name:Aliskiren

CBNumberCB9966226

SummenformelC30H53N3O6

Molgewicht551.76

MOL-Datei173334-57-1.mol

Aliskiren physikalisch-chemischer Eigenschaften

Schmelzpunkt	98-99 °C
Siedepunkt	748.4±60.0 °C(Predicted)
Dichte	1.067±0.06 g/cm3(Predicted)
storage temp.	Inert atmosphere,Store in freezer, under -20°C
Löslichkeit	DMSO : 100 mg/mL (181.24 mM; Need ultrasonic)
Aggregatzustand	Powder
pka	9.49(at 25℃)
Farbe	White to light yellow
CAS Datenbank	173334-57-1(CAS DataBase Reference)

Sicherheit

Giftige Stoffe Daten

173334-57-1(Hazardous Substances Data)

Gefahreninformationscode (GHS)

Aliskiren Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung
Aliskiren is a first-in-class antihypertensive drug that acts by direct inhibition of renin. It is indicated for oral administration either as monotherapy or in combination with other antihypertensive agents. Renin catalyzes the cleavage of angiotensin to form angiotensin I, the first and the rate-limiting step of the RAAS. The inhibition of renin by aliskiren results in reduced levels of angiotensin I, angiotensin II, and aldosterone, all of which contribute to the antihypertensive effect. RAAS modulators are among some of the most commonly prescribed antihypertensive agents to date.The most common side effect of aliskiren is diarrhea, particularly with doses higher than 300mg daily. Unlike ACE inhibition, direct inhibition of renin does not increase bradykinin levels. Elevated bradykinin levels are thought to be responsible for the angioderma and cough that occur commonly during treatment with ACE inhibitors. .
Originator
Novartis (Switzerland)
Verwenden
An orally active, synthetic nonpeptide renin inhibitor. Antihypertensive
Verwenden
liquid crystal intermediate
Definition
ChEBI: A monomethoxybenzene compound having a 3-methoxypropoxy group at the 2-position and a multi-substituted branched alkyl substituent at the 4-position.
Trademarks
Tekturna
Allgemeine Beschreibung
Aliskiren, (2S,4S,5S,7S)-5-amino-N-(2-carbamoyl-2-methyl-propyl)-4-hydroxy-7-{[4-methoxy-3-(3-methoxypropoxy)phenyl]methyl}-8-methyl-2-propan-2-yl-nonanamide (Tekturna), is the first renin inhibitorintroduced into the U. S. market. It was approved by theFDA in 2007 for the management of hypertension.The trade name for aliskiren in the United Kingdom isRasilez.

Aliskiren Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

173334-57-1, Aliskiren Verwandte Suche:

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