11β,17-Dihydroxypregn-4-en-3,20-dion-21-[(1-benzyl-1H-indazol-3-yl)oxy]acetat

11beta,17-dihydroxypregn-4-ene-3,20-dione 21-[(1-benzyl-1H-indazol-3-yl)oxy]acetate Chemische Eigenschaften,Einsatz,Produktion Methoden

• Originator

  Versacort,Angelini,Italy,1978

• Manufacturing Process

  Hydrocortisone (25 g) and bendazac chloride (21 g) are suspended in anhydrous dioxane (250 ml). Pyridine (6 ml) is added and the solution is kept under stirring for 2 hours at room temperature. Pyridine hydrochloride which separates is filtered and the clear dioxane solution is added, under strong stirring, to a solution of sodium bicarbonate (20 g) in distilled water (2,500 ml). The colorless precipitate which is formed is filtered, washed with water and dried on a porous plate. The substance crystallizes from ethanol. Needles. MP 174°-176°C. Yield: 75%.

• Therapeutic Function

  Glucocorticoid

• Sicherheitsprofil

  An experimental teratogen. Whenheated to decomposition it emits toxic fumes of NOx.

11beta,17-dihydroxypregn-4-ene-3,20-dione 21-[(1-benzyl-1H-indazol-3-yl)oxy]acetate Upstream-Materialien And Downstream Produkte

11β,17-Dihydroxypregn-4-en-3,20-dion-21-[(1-benzyl-1H-indazol-3-yl)oxy]acetat Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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