Diethyl[2-[2-(2-phenylbutyroyloxy)ethoxy]ethyl]ammoniumdihydrogencitrat

Bezeichnung:Diethyl[2-[2-(2-phenylbutyroyloxy)ethoxy]ethyl]ammoniumdihydrogencitrat

CAS-Nr18109-81-4

Englisch Name:Butamirate citrate

CBNumberCB9875076

SummenformelC24H37NO10

Molgewicht499.55128

MOL-Datei18109-81-4.mol

Synonyma

Diethyl[2-[2-(2-phenylbutyroyloxy)ethoxy]ethyl]ammoniumdihydrogencitrat

Diethyl[2-[2-(2-phenylbutyroyloxy)ethoxy]ethyl]ammoniumdihydrogencitrat physikalisch-chemischer Eigenschaften

Schmelzpunkt	66-68°C
storage temp.	Hygroscopic, Refrigerator, Under Inert Atmosphere
Löslichkeit	Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
Aggregatzustand	Solid
Farbe	White
InChIKey	JVKMHUAWFDGPTF-UHFFFAOYSA-N
SMILES	C1(C=CC=CC=1)C(CC)C(=O)OCCOCCN(CC)CC.C(O)(C(=O)O)(CC(=O)O)CC(=O)O

Butamirate citrate Chemische Eigenschaften,Einsatz,Produktion Methoden

Chemische Eigenschaften
White Solid
Originator
Sinecod,Hommel,Switz.,1967
Verwenden
Anxiolytic, Muscle Relaxant
Verwenden
Butamirate Citrate is a novel antitussive drug. It is used for the symptomatic treatment of non-productive (dry) cough.
Manufacturing Process
18.2 grams of α-phenylbutyric acid chloride are dissolved in 25 ml of toluene. To this solution, there is slowly added a solution of 16.1 grams of diethylaminoethoxyethanol in 25 ml of toluene, the reaction mixture thereby becoming hot. It is then heated for 8 hr under reflux. The reaction mixture, after cooling, is carefully poured onto 75 grams of ice and made alkaline with dilute ammonia. After thorough shaking of the solution, the toluene layer is removed and washed until neutral with water. The toluene solution is treated with carbon and dried over sodium sulfate. The toluene is distilled off from the filtered solution.
The residue is α-phenylbutyric acid diethylaminoethoxyethyl ester. The basic ester is purified by distillation in a high vacuum. 10 grams of ester are added to a solution of 7 grams of citric acid in 30 ml of warm acetone. After standing for some time, the citrate of the ester crystallizes out. After suction filtration and washing with acetone the ester citrate is recrystallized from acetone. The melting point of the citrate is 75°C.
Therapeutic Function
Antitussive
Allgemeine Beschreibung
Butamirate citrate is a non-opioid antitussive with a central effect on receptors in the brain stem. It has also been reported that it reduces bronchospasm with peripheral effect and has anti-inflammatory and anticholinergic effects. Therefore, it is thought to be effective in cough with both acute and chronic etiology.

Butamirate citrate Upstream-Materialien And Downstream Produkte

Diethyl[2-[2-(2-phenylbutyroyloxy)ethoxy]ethyl]ammoniumdihydrogencitrat Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

18109-81-4, Butamirate citrate Verwandte Suche:

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