Dimethoxanat

Dimethoxanate Chemische Eigenschaften,Einsatz,Produktion Methoden

• Originator

  Cothera,Ayerst,US,1957

• Definition

  ChEBI: Dimethoxanate is a member of phenothiazines.

• Manufacturing Process

  5.23 g of phenothiazine-10-carboxylic acid chloride were suspended in 8 g of dimethylaminoethoxyethanol and heated, with stirring, under anhydrous conditions, first for 1 hour at a temperature of 50°-105°C, then for another hour at 108°-110°C. All the suspended acid chloride had dissolved after the final heating, and the solution was then allowed to cool slowly to 75°C over a period of one hour. Infrared examination of a sample showed that the esterification reaction was essentially complete after the second hour
  The reaction mixture was then poured on 1 liter of crushed ice, and the oily precipitate washed repeatedly by decantation with ice water. It was then taken up in 75 ml of benzene, and again washed repeatedly with water until a pH of 8.2 in the washings indicated that substantially all of the excess β- dimethylaminoethoxyethanol had been removed. The benzene solution was then dried with anhydrous sodium sulfate, filtered, and the benzene evaporated in a current of dry nitrogen gas. The residual dark oil constituted the desired basic ester. β-Dimethylaminoethoxyethyl phenothiazine-10- carboxylate.
  The basic ester may be dissolved in anhydrous ether and then precipitated by adding a slight excess of a solution of dry hydrogen chloride in ether and the hydrochloride salt may be isolated as an amorphous, glasslike product, which could be crystallized from anhydrous acetone or from methanol-ether. In this manner there was obtained as a stable, crystalline, colorless substance β- dimethylaminoethoxyethyl phenothiazine-10-carboxylate hydrochloride, one sample of which melted at 161°-163°C with decomposition.

• Therapeutic Function

  Antitussive

Dimethoxanate Upstream-Materialien And Downstream Produkte

Dimethoxanat Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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