Dinatriumdisulfit

Bezeichnung:Dinatriumdisulfit

CAS-Nr7681-57-4

Englisch Name:Sodium metabisulfite

CBNumberCB9854280

SummenformelH2O5S2.2Na

Molgewicht192.12

MOL-Datei7681-57-4.mol

Synonyma

Dinatriumdisulfit

Dinatriumpyrosulfit

Natriummetabisulfit

Dinatriumdisulfit physikalisch-chemischer Eigenschaften

Schmelzpunkt	>300 °C (lit.)
Dichte	1.48
storage temp.	Store at +5°C to +30°C.
Löslichkeit	540 g/L (20°C)
Aggregatzustand	Powder/Solid
Wichte	1.48
Farbe	White to slightly yellow
PH	3.5-5 (50g/l, H2O, 20℃)
Geruch (Odor)	Sulphorous
Säure-Base-Indikators(pH-Indikatoren)	4.5 at 50 g/l at 20 °C
Wasserlöslichkeit	540 g/L (20 ºC)
Sensitive	Air & Moisture Sensitive
Merck	14,8638
Expositionsgrenzwerte	ACGIH: TWA 5 mg/m3 NIOSH: TWA 5 mg/m3
Stabilität	Stable. Incompatible with strong oxidizing agents, strong acids. Contact with strong acids releases a poisonous gas. May be moisture and air sensitive.
InChIKey	HRZFUMHJMZEROT-UHFFFAOYSA-L
CAS Datenbank	7681-57-4(CAS DataBase Reference)
EPA chemische Informationen	Sodium metabisulfite (7681-57-4)

Sicherheit

Kennzeichnung gefährlicher	Xn,Xi
R-Sätze:	22-31-41-36/37/38-52
S-Sätze:	26-39-46-36-16
RIDADR	3260
OEB	B
OEL	TWA: 5 mg/m3
WGK Germany	1
RTECS-Nr.	UX8225000
TSCA	Yes
HS Code	2832 10 00
PackingGroup	III
Giftige Stoffe Daten	7681-57-4(Hazardous Substances Data)
Toxizität	LD50 orally in Rabbit: 1540 mg/kg LD50 dermal Rat > 2000 mg/kg

Gefahreninformationscode (GHS)

Sodium metabisulfite Chemische Eigenschaften,Einsatz,Produktion Methoden

ERSCHEINUNGSBILD
WEISSES PULVER
CHEMISCHE GEFAHREN
Zersetzung beim Erhitzen unter Bildung von Schwefeloxiden. Starkes Reduktionsmittel. Reagiert mit Oxidationsmitteln. Reagiert sehr heftig mitkonzentrierter Natriumnitritlösung. Zersetzung bei Kontakt mit Säuren unter Bildung von Schwefeloxiden.
ARBEITSPLATZGRENZWERTE
TLV: 5 mg/m?(als TWA); Krebskategorie A4 (nicht klassifizierbar als krebserzeugend für den Menschen); (ACGIH 2005).
AUFNAHMEWEGE
Aufnahme in den Körper durch Inhalation und durch Verschlucken.
INHALATIONSGEFAHREN
Verdampfung bei 20°C vernachlässigbar; eine gesundheitsschädliche Partikelkonzentration in der Luft kann jedoch beim Dispergieren schnell erreicht werden.
WIRKUNGEN BEI KURZZEITEXPOSITION
WIRKUNGEN BEI KURZZEITEXPOSITION:
Die Substanz reizt die Augen, die Atemwege und reizt stark den Magen-Darm-Trakt. Inhalation kann zu Asthma führen.
LECKAGE
NICHT mit Sägemehl oder anderen brennbaren Absorptionsmitteln binden. Verschüttetes Material in Behältern sammeln; falls erforderlich durch Anfeuchten Staubentwicklung verhindern. Persönliche Schutzausrüstung: Atemschutzgerät, P2-Filter für schädliche Partikel. NICHT in die Umwelt gelangen lassen.
R-Sätze Betriebsanweisung:
R22:Gesundheitsschädlich beim Verschlucken.
R31:Entwickelt bei Berührung mit Säure giftige Gase.
R41:Gefahr ernster Augenschäden.
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S39:Schutzbrille/Gesichtsschutz tragen.
S46:Bei Verschlucken sofort ärztlichen Rat einholen und Verpackung oder Etikett vorzeigen.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
Aussehen Eigenschaften
Na2O5S2; Natriummetabisulfit, Natriumpyrosulfit, Pyrosulfit, Disulfit. Farbloser Feststoff mit charakteristischem Geruch.
Gefahren für Mensch und Umwelt
Gesundheitsschädlich beim Verschlucken. Gefahr ernster Augenschäden. Reizt die Atmungsorgane.
Nicht mit Säuren oder Oxidationsmitteln in Berührung bringen.
Setzt bei der Zersetzung Schwefeldioxid frei.
Entwickelt bei Berührung mit Säure giftige Gase.
LD₅₀ (i.v., Ratte) 115 mg/kg.
Schutzmaßnahmen und Verhaltensregeln
Schutzhandschuhe als kurzzeitiger Staubschutz.
Verhalten im Gefahrfall
Persönliche Maßnahmen: Substanzkontakt vermeiden.
Vorsichtig trocken aufnehmen. Der Entsorgung zuführen. Nachreinigen.
Auf Umgebung abstimmen.
Im Brandfall können Schwefeloxide freigesetzt werden.
Erste Hilfe
Nach Hautkontakt: Mit reichlich Wasser abwaschen.
Nach Augenkontakt: Mit reichlich Wasser bei geöffnetem Lidspalt mindestens 15 Minuten ausspülen. Sofort Augenarzt hinzuziehen.
Nach Einatmen: Frischluft. Arzt hinzuziehen.
Nach Verschlucken: Reichlich Wasser trinken. Erbrechen auslösen. Arzt hinzuziehen.
Nach Kleidungskontakt: Kontaminierte Kleidung entfernen.
Ersthelfer: siehe gesonderten Anschlag
Sachgerechte Entsorgung
Gelöst in Wasser zu den neutralen, wässrigen Lösemittelabfällen geben.
Chemische Eigenschaften
Sodium metabisulfite occurs as colorless, prismatic crystals or as a white to creamy-white crystalline powder that has the odor of sulfur dioxide and an acidic, saline taste. Sodium metabisulfite crystallizes from cold water as a hydrate containing seven water molecules.
Chemische Eigenschaften
Sodium metabisulfite is a white crystalline powder. Sulfur dioxide odor. It may be considered the anhydride of 2 molecules of sodium disulfite.
Verwenden
Sodium Metabisulfite is a preservative and antioxidant that exists as crystals or powder having a sulfur dioxide odor. it is readily solu- ble in water. it is used in dried fruits to preserve flavor, color, and to inhibit undesirable microorganism growth. it prevents “black spots” due to oxidative deterioration in shrimp. it is used in maraschino cherries. it is found in lemon drinks as a preservative. see sulfur dioxide.
Verwenden
Pharmaceutic aid (antioxidant).
Verwenden
sodium metabisulfite is an anti-oxidant and reducing agent.
Vorbereitung Methode
Sodium metabisulfite is prepared by saturating a solution of sodium hydroxide with sulfur dioxide and allowing crystallization to occur; hydrogen is passed through the solution to exclude air. Sodium metabisulfite may also be prepared by saturating a solution of sodium carbonate with sulfur dioxide and allowing crystallization to occur, or by thermally dehydrating sodium bisulfite.
Definition
ChEBI: An inorganic sodium salt composed of sodium and disulfite ions in a 2:1 ratio.
Allgemeine Beschreibung
Sodium metabisulfite (MBS, Sodium disulfite) is an inorganic salt. It is the sodium salt of disulphurous (pyrosulfurous) acid. It is widely used in textile dyeing, photography and paper industry. It is also commonly added to various food products and wines as a preservative.
Hazard
Toxic by inhalation. Upper respiratory tract irritant. Questionable carcinogen.
Health Hazard
Sodium metabisulfite may cause bronchospasm, oculonasal symptoms, and urticaria in sulfite-sensitive individuals; irritation of mucous membranes may occur from inhalation of the dust.
Flammability and Explosibility
Non flammable
Pharmazeutische Anwendungen
Sodium metabisulfite is used as an antioxidant in oral, parenteral, and topical pharmaceutical formulations, at concentrations of 0.01–1.0% w/v, and at a concentration of approximately 27% w/v in intramuscular injection preparations. Primarily, sodium metabisulfite is used in acidic preparations; for alkaline preparations, sodium sulfite is usually preferred. Sodium metabisulfite also has some antimicrobial activity, which is greatest at acid pH, and may be used as a preservative in oral preparations such as syrups.
In the food industry and in wine production, sodium metabisulfite is similarly used as an antioxidant, antimicrobial preservative, and antibrowning agent. However, at concentrations above about 550 ppm it imparts a noticeable flavor to preparations. Sodium metabisulfite usually contains small amounts of sodium sulfite and sodium sulfate.
Kontakt-Allergie
This agent is frequently used as a preservative in pharmaceutical products, in the bread-making industry as an antioxidant, and it can induce contact dermatitis. It can be used as a reducing agent in photography and caused dermatitis in a photographic technician, probably acting as an aggravating irritative factor. Sodium metabisulfite contains a certain amount of sodium sulfite and sodium sulfate.
Sicherheitsprofil
An inhalation hazard. Poison by intravenous route. Moderately toxic by parenteral route. Experimental reproductive effects. Mutation data reported. When heated to decomposition it emits toxic fumes of SOx and Na2O.
Sicherheit(Safety)
Sodium metabisulfite is widely used as an antioxidant in oral, topical, and parenteral pharmaceutical formulations; it is also widely used in food products.
Although it is extensively used in a variety of preparations, sodium metabisulfite and other sulfites have been associated with a number of severe to fatal adverse reactions. These are usually hypersensitivity-type reactions and include bronchospasm and anaphylaxis. Allergy to sulfite antioxidants is estimated to occur in 5–10% of asthmatics, although adverse reactions may also occur in nonasthmatics with no history of allergy.
Following oral ingestion, sodium metabisulfite is oxidized to sulfate and is excreted in urine. Ingestion may result in gastric irritation, owing to the liberation of sulfurous acid, while ingestion of large amounts of sodium metabisulfite can cause colic, diarrhea, circulatory disturbances, CNS depression, and death.
In Europe, the acceptable daily intake of sodium metabisulfite and other sulfites used in foodstuffs has been set at up to 3.5 mg/kg body-weight, calculated as sulfur dioxide (SO2). The WHO has similarly also set an acceptable daily intake of sodium metabisulfite, and other sulfites, at up to 7.0 mg/kg body-weight, calculated as sulfur dioxide (SO2).
LD50 (rat, IV): 0.12 g/kg
mögliche Exposition
Sodium metabisulfite is used as an antioxidant in pharmaceutical preparations and as a preservative in foods. People with asthma have a greater chance of having an allergic reaction with this chemical. Individuals allergic to sodium bisulfite (a food preservative found in some wine, fresh shrimp; packaged foods; and restaurant salads and potatoes) may have a severe reaction when exposed to sodium metabisulfite.
Carcinogenicity
Sodium metabisulfite was genotoxic in mice in vivo as determined by chromosomal aberration, micronucleus, and sperm shape assays. It was not mutagenic in bacterial assays.
Lager
On exposure to air and moisture, sodium metabisulfite is slowly oxidized to sodium sulfate with disintegration of the crystals. Addition of strong acids to the solid liberates sulfur dioxide.
In water, sodium metabisulfite is immediately converted to sodium (Na+) and bisulfite (HSO3-) ions. Aqueous sodium metabisulfite solutions also decompose in air, especially on heating. Solutions that are to be sterilized by autoclaving should be filled into containers in which the air has been replaced with an inert gas, such as nitrogen. The addition of dextrose to aqueous sodium metabisulfite solutions results in a decrease in the stability of the metabisulfite.
The bulk material should be stored in a well-closed container, protected from light, in a cool, dry place.
Versand/Shipping
UN1759 Corrosive solids, n.o.s., Hazard class: 8; Labels: 8-Corrosive material, Technical Name required. UN2693 Bisulfites, inorganic, aqueous solutions, n.o.s., Hazard class: 8; Labels: 8-Corrosive material.
Inkompatibilitäten
Sodium metabisulfite reacts with sympathomimetics and other drugs that are ortho- or para-hydroxybenzyl alcohol derivatives to form sulfonic acid derivatives possessing little or no pharmacological activity. The most important drugs subject to this inactivation are epinephrine (adrenaline) and its derivatives. In addition, sodium metabisulfite is incompatible with chloramphenicol owing to a more complex reaction; it also inactivates cisplatin in solution.
It is incompatible with phenylmercuric acetate when autoclaved in eye drop preparations.
Sodium metabisulfite may react with the rubber caps of multidose vials, which should therefore be pretreated with sodium metabisulfite solution.
Inkompatibilitäten
A strong reducing agent. Keep away from oxidizers. Mixtures with water forms a strong corrosive. Contact with acids releases toxic fumes. Heat causes decomposition. Slowly oxidized to the sulfate on exposure to air and moisture. Attacks metals
Regulatory Status
GRAS listed. Accepted for use as a food additive in Europe. Included in the FDA Inactive Ingredients Database (epidural;inhalation; IM and IV injections; ophthalmic solutions; oral preparations; rectal, topical, and vaginal preparations). Included in nonparenteral and parenteral medicines licensed in the UK. Included in the Canadian List of Acceptable Non-medicinal Ingredients.

Sodium metabisulfite Upstream-Materialien And Downstream Produkte

Dinatriumdisulfit Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

7681-57-4, Sodium metabisulfite Verwandte Suche:

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