1-Chlor-2-(chlordiphenylmethyl)benzol

Bezeichnung:1-Chlor-2-(chlordiphenylmethyl)benzol

CAS-Nr42074-68-0

Englisch Name:2-Chlorotrityl chloride

CBNumberCB9853612

SummenformelC19H14Cl2

Molgewicht313.22

MOL-Datei42074-68-0.mol

Synonyma

1-Chlor-2-(chlordiphenylmethyl)benzol

1-Chlor-2-(chlordiphenylmethyl)benzol physikalisch-chemischer Eigenschaften

Schmelzpunkt	130-135 °C
Siedepunkt	421.3±40.0 °C(Predicted)
Dichte	1.222±0.06 g/cm3(Predicted)
storage temp.	2-8°C
Löslichkeit	Soluble in Chloroform, methanol and dichloromethane, insoluble in water
Aggregatzustand	Powder
Farbe	Pale yellow crystalline powder
BRN	1983914
CAS Datenbank	42074-68-0(CAS DataBase Reference)

Sicherheit

Kennzeichnung gefährlicher	Xi
R-Sätze:	36/37/38
S-Sätze:	26-24/25-22
RIDADR	3261
WGK Germany	3
F	10-21
HS Code	2903 99 80
HazardClass	8
PackingGroup	III

Gefahreninformationscode (GHS)

2-Chlorotrityl chloride Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
Chemische Eigenschaften
off-white to yellow or brown beads
Verwenden
2-Chlorotrityl chloride is used as an intermediate of clotrimazole. It is also used in the preparation of modified trityl nucleosides as inhibitors of P. falciparum dUTPase. In addition, it serves as a protecting group reagent for carboxylic acids forming esters.
Application
2-Chlorotrityl Chloride is used in convergent peptide synthesis. Extremely acid labile resin for preparing peptide acids and partially protected peptide fragments by the Fmoc strategy. Cleavage can be effected by using AcOH/TFE/DCM or 0.5% TFA.
synthetische
2-Chlorotrityl chloride synthesis: It is esterified with 2-Chlorobenzoic acid and ethanol in the presence of sulfuric acid or p-toluenesulfonic acid to generate Ethyl 2-Chlorobenzoate, which is then condensed with phenylmagnesium bromide (Grignard reaction) to obtain (2-Chlorophenyl)diphenylmethanol magnesium salt is hydrolyzed with sulfuric acid to obtain (2-Chlorophenyl)diphenylmethanol, which is then chlorinated with thionyl chloride to obtain the product.
Biotechnological Applications
The 2-chlorotrityl chloride (2-CTC) resin is one of the most frequently used and most versatile resins for the large-scale manufacture of peptides. It is slightly less acid-labile than Trityl Resin and thus more widely used in solid phase peptide synthesis. Peptides UBI-8 and UBI-9 were synthesized by Fmoc-solid phase chemistry using a 2-chlorotrityl chloride linker-resin. Trityl linkers have certain advantages in comparison to the alkoxybenzyl alcohol (eg. Wang resin), especially in the area of peptide chemistry. First, the problem of racemization during the loading of the first amino acid (using DIPEA) is avoided with trityl linkers. Second, due to steric factors, no diketopiperazine formation is observed.

2-Chlorotrityl chloride Upstream-Materialien And Downstream Produkte

1-Chlor-2-(chlordiphenylmethyl)benzol Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

42074-68-0, 2-Chlorotrityl chloride Verwandte Suche:

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