L-tert-Leucine

Bezeichnung:L-tert-Leucine

CAS-Nr20859-02-3

Englisch Name:L-tert-Leucine

CBNumberCB9853319

SummenformelC6H13NO2

Molgewicht131.17

MOL-Datei20859-02-3.mol

L-tert-Leucine physikalisch-chemischer Eigenschaften

Schmelzpunkt	≥300 °C (lit.)
alpha	6.3 º (c=4, 6 N HCl 200 ºC)
Siedepunkt	217.7±23.0 °C(Predicted)
Dichte	1.1720 (estimate)
Brechungsindex	-9 ° (C=3, H2O)
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
Löslichkeit	1 M HCl: 50 mg/mL
Aggregatzustand	powder
pka	2.39±0.12(Predicted)
Farbe	White to almost white
Optische Aktivität	[α]20/D 9.5°, c = 3 in H2O
Wasserlöslichkeit	125.5 g/L (20 ºC)
BRN	1721824
InChIKey	NPDBDJFLKKQMCM-SCSAIBSYSA-N
CAS Datenbank	20859-02-3(CAS DataBase Reference)

Sicherheit

Kennzeichnung gefährlicher	Xi
S-Sätze:	22-24/25
WGK Germany	3
RTECS-Nr.	OH2850000
Hazard Note	Irritant
HS Code	29224999

Gefahreninformationscode (GHS)

L-tert-Leucine Chemische Eigenschaften,Einsatz,Produktion Methoden

S-Sätze Betriebsanweisung:
S22:Staub nicht einatmen.
S24/25:Berührung mit den Augen und der Haut vermeiden.
Chemische Eigenschaften
White to almost white powder
Verwenden
L-tert-Leucine is an essential amino acid and makes up one third of our muscle protein. It can be used as a food additive. It is used in the formation of sterols. It is used in the production of cobalt oxazoline palladacycles complex, which acts as a catalyst in the rearrangement of prochiral N-aryl trifluoroacetimidates to allylic amides yielded in significantly higher enantioselectivities with the (S)-(pR)-diasteroisomer.
Vorbereitung Methode
The synthesis method of L-tert-Leucine (L-Tle) includes chemical and biological methods. Compared with traditional chemical synthesis, the enzymatic reduction of chiral keto acid to synthesize the corresponding unnatural amino acid has the advantages of high optical purity, mild reaction conditions, high conversion rate, and environmental friendliness. Currently, enzymatic methods have gradually replaced chemical methods. Some previous research on preparing L-tert-leucine using hydrolase, acyltransferase, and amino acid dehydrogenase has been reported. Among them, the preparation of L-tert-leucine using NADH-dependent L-leucine dehydrogenase (LeuDH, EC 1.4.1.9) has exhibited the most industrial potential. In the presence of NADH and free ammonium, LeuDH can catalyze trimethylpyruvate (TMP) to L-tert-leucine[1-3].
Synthesis Reference(s)
Organic Syntheses, Coll. Vol. 3, p. 523, 1955
Tetrahedron Letters, 19, p. 4625, 1978 DOI: 10.1016/S0040-4039(01)85688-4
Allgemeine Beschreibung
L-tert-Leucine (L-Tle) is an essential non-natural amino acid often used as a template to induce asymmetric synthesis, and the product has high stereoselectivity. It is a non-polar amino acid, and its tert-butyl group has significant hydrophobicity and steric hindrance, which can control molecular conformation in a chemical reaction and form a chiral compound. Hence, L-tert-leucine is commonly used as an inducer or a template in asymmetric synthesis. As a vital chiral intermediate, L-tert-leucine is widely used to synthesise anti-cancer, anti-viral, and biological inhibitors. In addition, L-tert-leucine is an essential additive in the food and cosmetic industry[1].

L-tert-Leucine Upstream-Materialien And Downstream Produkte

L-tert-Leucine Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

20859-02-3, L-tert-Leucine Verwandte Suche:

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