Benzthiazid

Bezeichnung:Benzthiazid

CAS-Nr91-33-8

Englisch Name:BENZTHIAZIDE

CBNumberCB9758542

SummenformelC15H14ClN3O4S3

Molgewicht431.94

MOL-Datei91-33-8.mol

Synonyma

Benzthiazid

Benzthiazid physikalisch-chemischer Eigenschaften

Schmelzpunkt	231-232° (U.S. patent); mp 238-239° (P'an)
Siedepunkt	680.6±65.0 °C(Predicted)
Dichte	1.4176 (rough estimate)
Brechungsindex	1.6100 (estimate)
storage temp.	Refrigerator
Löslichkeit	DMSO (Slightly), Methanol (Slightly)
Aggregatzustand	Solid
pka	9.57±0.20(Predicted)
Farbe	White to Off-White
Wasserlöslichkeit	2.8mg/L(room temperature)
EPA chemische Informationen	2H-1,2,4-Benzothiadiazine-7-sulfonamide, 6-chloro-3-[[(phenylmethyl)thio]methyl]-, 1,1-dioxide (91-33-8)

Sicherheit

Kennzeichnung gefährlicher	Xn
R-Sätze:	42/43
S-Sätze:	26-36
WGK Germany	2
RTECS-Nr.	DK8400000
Giftige Stoffe Daten	91-33-8(Hazardous Substances Data)
Toxizität	LD50 in mice, rats (mg/kg): >5000, >10000 orally; 410, 422 i.v. (P'an)

Gefahreninformationscode (GHS)

BENZTHIAZIDE Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R42/43:Sensibilisierung durch Einatmen und Hautkontakt möglich.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
Originator
Exna,Robins,US,1960
Verwenden
Benzthiazide is a diuretic, antihypertensive agent.
Definition
ChEBI: 7-Sulfamoyl-1,2,4-benzothiadiazine 1,1-dioxide in which the hydrogen at position 6 is substituted by chlorine and that at position 3 is substituted by a benzylsulfanylmethyl group. A diuretic, it is used to treat hypertension and edema.
Manufacturing Process
The preparation of the dihydro analog is as follows:
(A) Preparation of 3-Chloromethyl-6-Chloro-7-Sulfamyl-3,4-DihydroBenzothiadizine-1,1-Dioxide - To 8 ml of 40-50% chloroacetaldehyde aqueous solution and 7 ml of dimethylformamide are added 10 grams of 2,4- disulfamyl-5-chloroaniline. The mixture is heated on a steam bath for 2 hours after which it is concentrated at reduced pressure. The residue is triturated with water. The solid material is recrystallized from methanol-ether after treatment with activated carbon to give 7.2 grams of product, MP 229°- 230°C.
(B) Preparation of Benzylthiomethyl-6-Chloro-7-Sulfamyl-3,4- Dihydrobenzothiadiazine-1,1-Dioxide - A mixture of 3-(chloromethyl)-6-chloro- 7-sulfamyl-3,4-dihydrobenzothiadiazine-1,1-dioxide (0.02 mol) and benzylmercaptan (0.024 mol) in 20 ml of 10% sodium hydroxide and 20 ml of dimethylformamide is stirred at room temperature for 6 hours. After heating for 10 minutes on a steam bath, the mixture is cooled and acidified with 6 N HCl. The product, after recrystallization from acetone, melts at 210°-211°C.
Trademarks
Aquatag (Solvay Pharmaceuticals); Fovane (Pfizer).
Therapeutic Function
Diuretic, Antihypertensive
Sicherheitsprofil
Poison by intravenous route. Adiuretic and antihypertensive agent. When heated todecomposition it emits very toxic fumes of SOx, NOx, andCl^-.

BENZTHIAZIDE Upstream-Materialien And Downstream Produkte

Benzthiazid Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

91-33-8, BENZTHIAZIDE Verwandte Suche:

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