2-(2-Bromethyl)-1,3-dioxan

Bezeichnung:2-(2-Bromethyl)-1,3-dioxan

CAS-Nr33884-43-4

Englisch Name:2-(2-Bromoethyl)-1,3-dioxane

CBNumberCB9715024

SummenformelC6H11BrO2

Molgewicht195.05

MOL-Datei33884-43-4.mol

Synonyma

2-(2-Bromethyl)-1,3-dioxan

2-(2-Bromethyl)-1,3-dioxan physikalisch-chemischer Eigenschaften

Schmelzpunkt	157-161 °C
Siedepunkt	67-70 °C2.8 mm Hg(lit.)
Dichte	1.431 g/mL at 25 °C(lit.)
Brechungsindex	n20/D 1.481(lit.)
Flammpunkt	206 °F
storage temp.	Keep in dark place,Inert atmosphere,2-8°C
Löslichkeit	ethanol: soluble50 (μg/mL)
Aggregatzustand	Liquid
Farbe	Clear colorless
Wasserlöslichkeit	It is not soluble in water but soluble in organic solvent such as ethanol.
BRN	1421628
InChI	InChI=1S/C6H11BrO2/c7-3-2-6-8-4-1-5-9-6/h6H,1-5H2
InChIKey	WMDHQEHPOVOEOG-UHFFFAOYSA-N
SMILES	O1CCCOC1CCBr
CAS Datenbank	33884-43-4(CAS DataBase Reference)
NIST chemische Informationen	2(2-Bromoethyl)-1,3-dioxane(33884-43-4)
EPA chemische Informationen	1,3-Dioxane, 2-(2-bromoethyl)- (33884-43-4)

Sicherheit

Kennzeichnung gefährlicher	Xi
R-Sätze:	36/37/38
S-Sätze:	26-24/25
WGK Germany	3
F	8-10
TSCA	Yes
HS Code	29349990

Gefahreninformationscode (GHS)

2-(2-Bromoethyl)-1,3-dioxane Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
Verwenden
2-(2-Bromoethyl)-1,3-dioxane was used in the synthesis of ketone adducts 2-[3-oxo-4(S)-(triphenylmethyl) amino-6-methylheptyl]-1,3-dioxane and 2-[3-oxo-4(S)-(triphenylmethyl)amino-6-methylheptyl]-1,3-dioxolane.
Allgemeine Beschreibung
The reaction of Grignard reagent prepared from 2-(2-bromoethyl)-1,3-dioxane and N-tert-butanesulfinyl aldimines was studied.
Synthese
A 2-L, three-necked flask has a mechanical stirrer, thermometer, and gas inlet tube. In the flask, 750 mL of dichloromethane, 112 g (2.00 mol) of acrolein (Note 1), and 0.10 g of dicinnamalacetone indicator are placed under nitrogen. The yellow solution is cooled to 0–5°C with an ice bath. Gaseous hydrogen bromide is bubbled into the solution with stirring until the indicator becomes deep red. The ice bath is removed, and 1.0 g of p-toluenesulfonic acid monohydrate and 152.2 g (2.00 mol, 144 mL) of 1,3-propanediol are added. The yellow solution is stirred at room temperature for 8 hr and then concentrated with a rotary evaporator. The residual oil is washed with two 250-mL portions of saturated aqueous sodium bicarbonate and dried over anhydrous potassium carbonate. Vacuum distillation through a 30-cm Vigreux column yields 252 g (65%) of 2-(2-Bromoethyl)-1,3-dioxane as a colourless liquid.
Lager
This bromide is recognized to possess irritant properties and should therefore invariably be handled with gloved hands inside an efficient hood. It is also advisable that these reagents be refrigerated for long-term storage in order to minimize the potential for acid liberation.

2-(2-Bromoethyl)-1,3-dioxane Upstream-Materialien And Downstream Produkte

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