Dinatriumdihydrogen(3-amino-1-hydroxypropyliden)bisphosphonat

Bezeichnung:Dinatriumdihydrogen(3-amino-1-hydroxypropyliden)bisphosphonat

CAS-Nr57248-88-1

Englisch Name:Pamidronate disodium salt

CBNumberCB9707409

SummenformelC3H12NNaO7P2

Molgewicht259.07

MOL-Datei57248-88-1.mol

Synonyma

Dinatriumdihydrogen(3-amino-1-hydroxypropyliden)bisphosphonat

Dinatriumdihydrogen(3-amino-1-hydroxypropyliden)bisphosphonat physikalisch-chemischer Eigenschaften

Schmelzpunkt	300 °C
storage temp.	2-8°C
Löslichkeit	H₂O: 28 mg/mL
Aggregatzustand	solid
Farbe	white
Merck	14,7003
Stabilität	Hygroscopic
CAS Datenbank	57248-88-1(CAS DataBase Reference)

Sicherheit

Kennzeichnung gefährlicher	Xn
R-Sätze:	22-48-41-37/38-20/21/22
S-Sätze:	22-26-36/37/39-45
RIDADR	3077
WGK Germany	3
RTECS-Nr.	SZ6525000
HazardClass	IRRITANT
HS Code	29319090

Gefahreninformationscode (GHS)

Pamidronate disodium salt Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R22:Gesundheitsschädlich beim Verschlucken.
R48:Gefahr ernster Gesundheitsschäden bei längerer Exposition.
R41:Gefahr ernster Augenschäden.
R37/38:Reizt die Atmungsorgane und die Haut.
R20/21/22:Gesundheitsschädlich beim Einatmen,Verschlucken und Berührung mit der Haut.
S-Sätze Betriebsanweisung:
S22:Staub nicht einatmen.
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36/37/39:Bei der Arbeit geeignete Schutzkleidung,Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn möglich, dieses Etikett vorzeigen).
Beschreibung
Disodium pamidronate is a calcium metabolism regulator useful in the treatment of hypercalcemia associated with malignancy. It presumably reduces the bone resorption of calcium by inhibiting the formation and attachment of osteoclasts. Other potential uses include osteoporosis and calcitonin-resistant Paget’s disease.
Chemische Eigenschaften
White Crystals
Originator
Henkel (United Kingdom)
Verwenden
A bisphosphonate antiresorptive agent; bone resorption inhibitor.
Verwenden
A farnesyl diphosphate synthase inhibitor
Verwenden
Pamidronate disodium is a nitrogen containing bisphosphonate, used to prevent osteoporosis. It is used to prevent bone loss, and treat osteoporosis.
Manufacturing Process
For a batch size of 5 L, 587.5 g (3.2 moles) of mannitol is dissolved in 3.5 L of water. Pamidronic acid (31.6 g, 0.133 moles) is mixed with a 1.0 L aliquot of the mannitol solution to form a slurry. The slurry is then transferred into the remainder of the mannitol solution, and stirred for at least 15 min. Aqueous 1 N sodium hydroxide (270 ml) is then added and the mixture is stirred until a clear, colorless solution results. The pH is then adjusted to 6.50.1 using either 1 M aqueous phosphoric acid or 1 N aqueous sodium hydroxide, as needed. The solution is then filtered through a 0.22 micron filter, and filled at 20°C into vials at 4.0 ml (4.172 g)/vial, under sterile conditions. The aqueous solution is frozen at -37°C and lyophilized (20 mbar, 20°-40°C) to yield 1,250 vials, each containing 30 mg of amorphous disodium pamidronate. The vials are sealed under positive nitrogen pressure. The disodium pamidronate is amorphous (noncrystalline) by X-ray diffraction and contains 0.7 wt-% water.
Trademarks
Aredia (Novartis).
Therapeutic Function
Bone resorption suppressant
Biochem/physiol Actions
Pamidronate disodium?has the ability to block Wnt and β-catenin signaling, which modulates the osteogenic differentiation in bone marrow mesenchymal stem cells (BMMSCs). It can also reduce bilirubin-impaired apoptosis and helps to develop dentinogenic dysfunction of stem cells from human deciduous teeth.
Veterinary Drugs and Treatments
Pamidronate may be useful in treating hypercalcemia associated with vitamin D-related toxicoses or hypercalcemia of malignancy. There is ongoing research on the use of this drug to determine if it has clinical usefulness in directly treating “micro-metastases” in osteosarcomas.

Pamidronate disodium salt Upstream-Materialien And Downstream Produkte

Dinatriumdihydrogen(3-amino-1-hydroxypropyliden)bisphosphonat Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

57248-88-1, Pamidronate disodium salt Verwandte Suche:

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