RK-682 Struktur

RK-682

Bezeichnung:RK-682

CAS-Nr154639-24-4

Englisch Name:RK-682

CBNumberCB9706972

SummenformelC21H36O5

Molgewicht368.51

MOL-Datei154639-24-4.mol

RK-682 physikalisch-chemischer Eigenschaften

Siedepunkt	546.7±50.0 °C(Predicted)
Dichte	1.073±0.06 g/cm3(Predicted)
storage temp.	Store at -20°C
Löslichkeit	Methanol: soluble
Aggregatzustand	Pale yellow solid.
pka	1.80±0.10(Predicted)

RK-682 Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung
TAN 1364B is a protein tyrosine phosphatase (PTP) inhibitor and the racemic and monomeric form of RK-682 . TAN 1364B inhibits the activity of the PTPs LMW-PTP, CDC25B, and PTP1B (IC₅₀s = 8.6, 12.4, and 0.7 μM, respectively), but the inhibitory activity against LMW-PTP and CDC25B is blocked in the presence of magnesium. TAN 1364B forms aggregates in solution and binds to both the PTP binding site and to protein surfaces.
Verwenden
TAN 1364B is the most abundant analogue of a tetronic acid complex isolated from Streptomyces species, first patented by Takeda in 1993 and more formally identified by Ciba Geigy as the sodium salt of 3-hexadecanoyl-5-hydroxymethyltetronic acid. In 1995 researchers at RIKEN reported the isolation of 3-hexadecanoyl-5-hydroxymethyltetronic acid, named as RK-682. Subsequent synthesis in 2001 showed that the RIKEN RK-682 was in fact the calcium complex of TAN 1364B formed as an artefact during silica chromatography. As the complex, salt or free acid, TAN 1364B inhibits protein tyrosine phosphatases, phospoholipase A2, heparinase and HIV-1 protease. However, it is unclear whether biological activity is due to the monomer (TAN 1364B) or dimeric complex (RK-682)
Verwenden
TAN 1364B (RK-682) is the most abundant analogue of a tetronic acid complex isolated from Streptomyces species, first patented by Takeda in 1993 and more formally identified by Ciba Geigy as the sodium salt of 3-hexadecanoyl-5-hydroxymethyltetronic acid. In 1995 researchers at RIKEN reported the isolation of 3-hexadecanoyl-5-hydroxymethyltetronic acid, named as RK-682. Subsequent synthesis in 2001 showed that the RIKEN RK-682 was in fact the calcium complex of TAN 1364B formed as an artefact during silica chromatography. As the complex, salt or free acid, TAN 1364B inhibits protein tyrosine phosphatases, phospoholipase A2, heparinase and HIV-1 protease. However, it is unclear whether biological activity is due to the monomer (TAN 1364B) or dimeric complex (RK-682)

RK-682 Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

154639-24-4, RK-682 Verwandte Suche:

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