Harman

Bezeichnung:Harman

CAS-Nr486-84-0

Englisch Name:HARMANE

CBNumberCB9698060

SummenformelC12H10N2

Molgewicht182.22

MOL-Datei486-84-0.mol

Synonyma

Harman

Harman physikalisch-chemischer Eigenschaften

Schmelzpunkt	235-238 °C(lit.)
Siedepunkt	305.62°C (rough estimate)
Dichte	1.1485 (rough estimate)
Brechungsindex	1.6266 (estimate)
storage temp.	Store at RT
Löslichkeit	methanol: soluble50mg/ml
pka	7.37, 14.6(at 25℃)
Aggregatzustand	Solid
Farbe	White to Dark Brown
Wasserlöslichkeit	1523g/L(20 ºC)
Merck	13,4630
BRN	143898
LogP	3.100
CAS Datenbank	486-84-0(CAS DataBase Reference)

Sicherheit

Kennzeichnung gefährlicher	Xn,Xi
R-Sätze:	20/21-36/37/38
S-Sätze:	22-24/25-36-26
RIDADR	1544
WGK Germany	3
RTECS-Nr.	UV0280000
HazardClass	6.1(b)
PackingGroup	III
Toxizität	LD50 i.p. in mice: 50 mg/kg (Sigg)

Gefahreninformationscode (GHS)

HARMANE Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R20/21:Gesundheitsschädlich beim Einatmen und bei Berührung mit der Haut.
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-Sätze Betriebsanweisung:
S22:Staub nicht einatmen.
S24/25:Berührung mit den Augen und der Haut vermeiden.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
Chemische Eigenschaften
Off-White Solid
Verwenden
- Harmane was used in trace level determination of harmane by planar chromatography coupled with (tandem) mass spectrometry.
- It was used to study interactions of norharman and harman with DNA.
- It may be used as matrix for analysis of cyclodextrins and for sulfated oligosaccharides in combination with DHB as co-matrix.
Verwenden
Harman alkaloid like harmane, harmine, harmalol, harmaline obtained from Banisteriopsis caapi L. showed cytotoxicity, antimicrobial activity against Staphylococcus aureus, Escherichia coli, Proteus vulgaris and Candida albicans.
Definition
ChEBI: An indole alkaloid fundamental parent with a structure of 9H-beta-carboline carrying a methyl substituent at C-1. It has been isolated from the bark of Sickingia rubra, Symplocus racemosa, P ssiflora incarnata, Peganum harmala, Banisteriopsis caapi and Tribulus terrestris, as well as from tobacco smoke. It is a specific, reversible inhibitor of monoamine oxidase A.
Synthesis Reference(s)
The Journal of Organic Chemistry, 37, p. 1429, 1972 DOI: 10.1021/jo00974a030
Tetrahedron, 49, p. 3325, 1993 DOI: 10.1016/S0040-4020(01)90161-9
Allgemeine Beschreibung
- Harmane is a potent tremor-producing β-carboline alkaloid and neurotoxin.
- It is major representative of heterocyclic aromatic amines, a group of mutagenic and carcinogenic substances which are formed in meat from the precursors creatine, creatinine, amino acids and sugars during the heating at high temperatures.
- Blood harmane concentration is elevated in essential tremor, late-life neurological disease.
Biologische Aktivität
Proposed as the endogenous ligand for imidazoline binding sites. Binds to I 1 -sites in rat kidney with an IC 50 of 31 nM, and I 2 -sites with a K i of 49 nM. In vivo, produces a dose-dependent hypotension that is reversed by efaroxan (2-(2-Ethyl-2,3-dihydro-2-benzofuranyl)-4,5-dihydro-1H-imidazole hydrochloride ). Also a potent inhibitor of monoamine oxidases A and B (I 50 values are 0.5 and 5 μ M respectively).
Biochem/physiol Actions
I1 imidazoline binding site agonist.
Lager
Room temperature

Harman Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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