1,6-BIS(CYCLOHEXYLOXIMINOCARBONYLAMINO)HEXANE Struktur

1,6-BIS(CYCLOHEXYLOXIMINOCARBONYLAMINO)HEXANE

Bezeichnung:1,6-BIS(CYCLOHEXYLOXIMINOCARBONYLAMINO)HEXANE

CAS-Nr83654-05-1

Englisch Name:1,6-BIS(CYCLOHEXYLOXIMINOCARBONYLAMINO)HEXANE

CBNumberCB9686432

SummenformelC20H34N4O4

Molgewicht394.52

MOL-Datei83654-05-1.mol

1,6-BIS(CYCLOHEXYLOXIMINOCARBONYLAMINO)HEXANE physikalisch-chemischer Eigenschaften

Schmelzpunkt	118-121℃
Dichte	1.21±0.1 g/cm3(Predicted)
RTECS-Nr.	GW1485000
storage temp.	Sealed in dry,Room Temperature
Löslichkeit	DMSO: 9 mg/mL
Aggregatzustand	solid
pka	13.81±0.46(Predicted)
Farbe	white
Stabilität	Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months

Sicherheit

S-Sätze:	22-24/25
WGK Germany	3

Gefahreninformationscode (GHS)

1,6-BIS(CYCLOHEXYLOXIMINOCARBONYLAMINO)HEXANE Chemische Eigenschaften,Einsatz,Produktion Methoden

S-Sätze Betriebsanweisung:
S22:Staub nicht einatmen.
S24/25:Berührung mit den Augen und der Haut vermeiden.
Beschreibung
RHC-80267 (83654-05-1) inhibits DAG Lipase activity in a variety of cell types and tissues, including canine platelets, bovine adrenal chromaffin cells, human adrenal glomerulosa cells, rat thyroid lobes and pancreatic minilobules. IC50 in canine platelets is 4 μM.1
Verwenden
RHC-80267 is a selective inhibitor of DAG lipase, which plays an important role in the production of arachidonic acid.
Definition
ChEBI: N-[6-[[(cyclohexylideneamino)oxy-oxomethyl]amino]hexyl]carbamic acid (cyclohexylideneamino) ester is a carbamate ester and an organonitrogen compound.
Allgemeine Beschreibung
Selective inhibitor of DAG lipase activity in canine platelets (IC₅₀ = 4 nM) and in a variety of mammalian cells. Also inhibits glucose- and carbachol-induced insulin release from intact islets. An inhibitor of Angiotensin II (Cat. No. 05-23-0101) and ATP-induced synthesis of 6-keto-prostaglandin F1α.
Biologische Aktivität
Inhibitor of diacylglycerol lipase (IC 50 values are 1.1 and 4 μ M in rat cardiac myocytes and canine platelets respectively). Weakly inhibits phospholipases C and A 2 . Potentiates acetylcholine evoked relaxation in mesenteric arteries by the inhibition of cholinesterase activity (IC 50 = 4 μ M).
Biochem/physiol Actions
Product does not compete with ATP.
Lager
Store at +4°C
Einzelnachweise
1) Southerland and Amin (1982), Anthranilic acid amides: a novel class of antiangiogenic VEGF receptor kinase inhibitors; J. Biol. Chem., 257 14006 2) Rindlisbacher et al. (1990), Advances in the structural biology, design and clinical development of VEGF-R kinase inhibitors for the treatment of angiogenesis; J. Neurochem., 54 1247 3) Chandra Sekar et al. (1987), Anthranilic acid amides: a novel class of antiangiogenic VEGF receptor kinase inhibitors; Arch. Biochem. Biophys., 256 509 4) Levasseur et al. (1984), Advances in the structural biology, design and clinical development of VEGF-R kinase inhibitors for the treatment of angiogenesis; Prostaglandins, 27 673 5) Natarajan et al. (1988), Anthranilic acid amides: a novel class of antiangiogenic VEGF receptor kinase inhibitors; Biochem. Biophys. Res. Commun., 156 717

1,6-BIS(CYCLOHEXYLOXIMINOCARBONYLAMINO)HEXANE Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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