Diflunisal Produkt Beschreibung

Diflunisal Struktur
22494-42-4
  • CAS-Nr.22494-42-4
  • Bezeichnung:Diflunisal
  • Englisch Name:Diflunisal
  • Synonyma:Diflunisal
    mk647;Adomal;MK 647;Dolisal;Dolobid;Dolobil;Dolobis;Flustar;Difludol;Flovacil
  • CBNumber:CB9674965
  • Summenformel:C13H8F2O3
  • Molgewicht:250.2
  • MOL-Datei:22494-42-4.mol
Diflunisal physikalisch-chemischer Eigenschaften
  • Schmelzpunkt: :207-209?C
  • Dichte :1.3505 (estimate)
  • storage temp.  :Refrigerator
  • Löslichkeit :Practically insoluble in water, soluble in ethanol (96 per cent). It dissolves in dilute solutions of alkali hydroxides.
  • Aggregatzustand :neat
  • pka :pKa 3.3 (H2O I=0.1) (Uncertain)
  • CAS Datenbank :22494-42-4(CAS DataBase Reference)
  • NIST chemische Informationen :Diflunisal(22494-42-4)
Sicherheit
  • Kennzeichnung gefährlicher :Xn,Xi
  • R-Sätze: :22-36/37/38-63
  • S-Sätze: :22-26-36
  • WGK Germany  :3
  • RTECS-Nr. :DV2030000
  • Hazard Note  :Irritant
  • HS Code  :2918290000
  • Toxizität :LD50 orally in female mice: 439 mg/kg (Stone)

Diflunisal Chemische Eigenschaften,Einsatz,Produktion Methoden

  • R-Sätze Betriebsanweisung: R22:Gesundheitsschädlich beim Verschlucken.
    R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
    R63:Kann das Kind im Mutterleib möglicherweise schädigen.
  • S-Sätze Betriebsanweisung: S22:Staub nicht einatmen.
    S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
    S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
  • Chemische Eigenschaften White Solid
  • Verwenden Salicylate; non-selective cyclo-oxygenase inhibitor; antipyretic; analgesic; anti- inflammatory.
  • Trademarks Dolobid (Merck).
  • Allgemeine Beschreibung Diflunisal (Dolobid), is a longer acting and more potent drugthan aspirin because of its hydrophobic, 2,4-difluorophenylgroup attached to the 5-position of the salicyclic acid. In alarge-scale comparative study with aspirin, it was also bettertolerated with less GI complications than aspirin. It ismarketed in tablet form for treating mild to moderate postoperativepain as well as RA and OA.
    Diflunisal is highly protein bound. Its metabolism is subjectto a dose-dependent, saturable, and capacity-limitedglucuronide formation. This unusual pharmacokineticprofile is a result of an enterohepatic circulation and the reabsorptionof 65% of the drug and its glucuronides, followedby cleavage of its unstable, acyl glucuronide back tothe active drug. Thus, diflunisal usage in patients with renalimpairment should be closely monitored.
  • Sicherheitsprofil Poison by ingestion, subcutaneous, and intraperitoneal routes. Human systemic effects by ingestion: tolerance, and cholestatic jaundce (due to the stoppage of the flow of bile), agranulocytosis, increased body temperature. An experimental teratogen. Other experimental reproductive effects. An analgesic and anti-inflammatory agent. When heated to decomposition it emits toxic fumes of F-. See also FLUORIDES.
Diflunisal Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Diflunisal Anbieter Lieferant Produzent Hersteller Vertrieb Händler.
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22494-42-4, Diflunisal Verwandte Suche:
  • DIFLUSINAL
  • LABOTEST-BB LT00771921
  • 2',4'-DIFLUORO-4-HYDROXY[1,1'-BIPHENYL]-3-CARBOXYLIC ACID
  • 2',4'-DIFLUORO-4-HYDROXY-BIPHENYL-3-CARBOXYLIC ACID
  • 5-[2,4-DIFLUOROPHENYL]SALICYLIC ACID
  • [1,1'-Biphenyl]-3-carboxylic acid, 2',4'-difluoro-4-hydroxy-
  • 1’-biphenyl)-3-carboxylicacid,2’,4’-difluoro-4-hydroxy-(
  • 1’-biphenyl]-3-carboxylicacid,2’,4’-difluoro-4-hydroxy-[
  • 2-(Hydroxy)-5-(2,4-difluorophenyl)benzoic acid
  • 2-(hydroxy)-5-(2,4-difluorophenyl)benzoicacid
  • 2',4'-Difluoro-4-hydroxy-(1',1-diphenyl)-3-carboxylic acid
  • 2',4'-Difluoro-4-hydroxy-3-biphenylcarboxylic acid
  • 2’,4’-difluoro-4-hydroxy-3-biphenylcarboxylicaci
  • 2’,4’-difluoro-4-hydroxy-3-biphenylcarboxylicacid
  • 3-Biphenylcarboxylic acid, 2',4'-difluoro-4-hydroxy-
  • Adomal
  • Difludol
  • Dolisal
  • Dolobid
  • Dolobil
  • Dolobis
  • Flovacil
  • Fluniget
  • Fluodonil
  • Flustar
  • MK 647
  • mk647
  • DIFLUNISAL,USP
  • 5-(2,4-DIFLUOROPHENYL)SALICYLICACID(DIFLUNISAL)
  • DIFLUCORTOLONE
  • 5-(2,4-Difluorophenyl)-2-hydroxybenzoic acid
  • Diflunisal
  • Diflunisal,5-(2,4-Difluorophenyl)salicylic acid
  • Diflunisal (200 mg)
  • 2',4'-Difluoro-4-hydroxy-
  • Diflunusal
  • Diflunisal,DOLOBID, Dolisal, Dorbid, Dugodol, MK-647, Donobid
  • 22494-42-4
  • C13H8F2O3
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