GSK840

GSK840 Chemische Eigenschaften,Einsatz,Produktion Methoden

• Biologische Aktivität

  GSK840 is a receptor-interacting protein kinase 3 (RIP3 or RIPK3) inhibitor, binds with high affinity to the RIP3 kinase domain with an IC50 of 0.9 nM, and inhibits kinase activity with an IC50 of 0.3 nM.

• in vitro

  GSK840 (GSK'840) (0.01-3 μM; 24 hours) blocks TNF-induced necroptosis in a concentration-dependent manner.
  GSK840 binds the kinase domain and inhibits kinase activity with high specificity, targeting a broader range of pro-necrotic stimuli than can be achieved with RIP1 kinase inhibitors.

  Cell Viability Assay

  Cell Line:	Human HT-29 cells (TNF 10 ng/ml + zVAD-fmk 20 μM + SMAC007 100 nM)
  Concentration:	0.01-3 μM
  Incubation Time:	24 hours
  Result:	Blocked TNF-induced necroptosis in a concentration-dependent manner.

• target

  IC50: 0.3 nM (RIP3)

GSK840 Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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