PROTOPANAXTRIOL

Bezeichnung:PROTOPANAXTRIOL

CAS-Nr34080-08-5

Englisch Name:PROTOPANAXTRIOL

CBNumberCB9511866

SummenformelC30H52O4

Molgewicht476.74

MOL-Datei34080-08-5.mol

PROTOPANAXTRIOL physikalisch-chemischer Eigenschaften

Schmelzpunkt	242-244 °C
Siedepunkt	590.0±50.0 °C(Predicted)
Dichte	1.079
storage temp.	-20°C Freezer
Löslichkeit	Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
Aggregatzustand	Solid
pka	14.73±0.70(Predicted)
Farbe	Off-White
InChIKey	SHCBCKBYTHZQGZ-NSMZZYIQNA-N
SMILES	O[C@H]1[C@H]2[C@@]([C@]3([C@@H]([C@@]4([C@@H]([C@H](C3)O)C([C@H](CC4)O)(C)C)C)C1)C)(CC[C@@H]2[C@@](O)(CCC=C(C)C)C)C
LogP	5.890 (est)

Sicherheit

WGK Germany	3
HS Code	29061990
Speicherklasse	11 - Combustible Solids

PROTOPANAXTRIOL Chemische Eigenschaften,Einsatz,Produktion Methoden

Chemische Eigenschaften
White crystalline powder, soluble in organic solvents such as methanol, ethanol, and DMSO, derived from ginseng.
Verwenden
(20S)-Protopanaxatriol acts as an inhibitor in the production of corticosteroids in fasciculata cells. Used in the clinical treatment of heart diseases.
Definition
ChEBI: Protopanaxatriol is a tetracyclic triterpenoid sapogenin (isolated from ginseng and notoginseng) that is that is dammarane which is substituted by hydroxy groups at the 3beta, 6alpha, 12beta and 20 pro-S positions and in which a double bond has been introduced at the 24-25 position. It has a role as a metabolite. It is a tetracyclic triterpenoid, a sapogenin, a 3beta-hydroxy steroid, a 12beta-hydroxy steroid, a 6alpha-hydroxy steroid and a 3beta-hydroxy-4,4-dimethylsteroid. It derives from a hydride of a dammarane.
Biologische Aktivität
A metabolites of ginsenoside, protopanaxatriol (g-PPT), could modulate endothelial cell functions through the glucocorticoid receptor (GR) and oestrogen receptor (ER).

in vivo

(20S)-Protopanaxatriol (10mg/kg; i.p.; daily for four weeks) synergizes with Gefitinib to inhibit xenograft growth^[3].
(20S)-Protopanaxatriol (50-100 mg/kg; p.o.; 25 days; female BALB/c nude mice bearing breast cancer MCF-7 cell) inhibits the growth of MCF-7 breast cancer cells in a nude mice xenograft assay^[4].

Animal Model:	H1975 murine xenograft tumor model
Dosage:	10mg/kg
Administration:	I.p.; daily for four weeks
Result:	The combined g-PPT and Gefitinib (50 mg/kg/day) treatment clearly reduced p-EGFR and KI67 expression and increased c-Caspase3 expression compared to Gefitinib or g-PPT treatment alone.

target
Antifection | Glucocorticoid receptor | Oestrogen receptor | LXRα

PROTOPANAXTRIOL Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

34080-08-5, PROTOPANAXTRIOL Verwandte Suche:

Send Inquriy