B-HT 933 DIHYDROCHLORIDE Struktur

B-HT 933 DIHYDROCHLORIDE

Bezeichnung:B-HT 933 DIHYDROCHLORIDE

CAS-Nr36067-72-8

Englisch Name:B-HT 933 DIHYDROCHLORIDE

CBNumberCB9496972

SummenformelC9H16ClN3O

Molgewicht217.7

MOL-Datei36067-72-8.mol

B-HT 933 DIHYDROCHLORIDE physikalisch-chemischer Eigenschaften

storage temp.	Desiccate at RT
Löslichkeit	H₂O: >20 mg/mL
Aggregatzustand	solid
Farbe	white to off-white

Sicherheit

WGK Germany	2
RTECS-Nr.	RQ5831345

B-HT 933 DIHYDROCHLORIDE Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung
B-HT 933 is an agonist of α₂-adrenergic receptors (α₂-ARs) with an EC₅₀ value of 0.65 μM for contraction of canine sapheneous veins. It induces concentration-dependent inhibition of the twitch response in rat vas deferens and guinea pig ileum. B-HT 933 induces sedation and reduces motor activity in mice, an effect that is reversed by the α₂-AR antagonist yohimbine . B-HT 933 decreases blood pressure and cardiac output in cats injected with 30 μg/kg intracisternally. It also exhibits antinociceptive effects in mice with ED₅₀ values of 12.5, 20.5, and 6.1 mg/kg for the tail-immersion, tail-pinch, and acetic acid writhing tests, respectively.
Verwenden
B-HT 933 Dihydrochloride is a selective α2-adrenoceptor agonist and has less potent inhibitory effect on the sympathetic vasopressor responses in diabetic rats.
in vitro
b-ht 933, a selective α2-adrenoceptor agonist, contracts human subcutaneous resistance arteries by a mechanism largely dependent on the influx of extracellular ca2+, probably through voltage-operated calcium channels. this action involves a pertussis toxin-sensitive g protein, possibly gq [1].
in vivo
the dose-related effects of the selective α2-adrenoceptor agonist b-ht 933 on the body temperature of untreated and reserpine-treated mice were investigated. in untreated mice b-ht 933 induced a dose-related hypothermia. the highest dose of b-ht 933 elicited a marked hypothermia, whereas the maximal hypothermic effect of clonidine was less pronounced and reached a plateau at a dose of 0.5 mg/kg [2].
IC 50
0.44 μm
Lager
Desiccate at RT
Einzelnachweise
[1] n. a. parkinson & a.d. hughes. the mechanism of action of 1c2-adrenoceptors in human isolated subcutaneous resistance arteries. british journal of pharmacology (1995) 115, 1463-1468
[2] d. j. bill, i.e. hughes & r.j. stephens. the thermogenic actions of x2-adrenoceptor agonists in reserpinized mice are mediated via a central postsynaptic ac2-adrenoceptor mechanism. br. j. pharmacol. (1989), 96, 133-143

B-HT 933 DIHYDROCHLORIDE Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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