Asp-AMS

Asp-AMS Chemische Eigenschaften,Einsatz,Produktion Methoden

• Biologische Aktivität

  Asp-AMS is an analog of aspartate adenylate, an inhibitor of aspartyl-tRNA synthetase, and a potent and competitive inhibitor of mitochondrial enzyme.

• in vitro

  Asp-AMS is a 500-fold stronger competitive inhibitor of the mitochondrial enzyme than aspartol-AMP (10 nM) and a 35-fold lower competitor of human and bovine cyt-AspRSs (300 nM).It is a strong inhibitor with K _i in the nanomolar (nM) range.It has also the highest inhibitory effect for the mitochondrial enzyme.It is the most active inhibitor with K _i values in the nanomolar range, with a stronger effect on bacterial AspRSs ( E. coli and P. aeruginosa ) than on human cytosolic AspRS.

• target

  Aspartyl-tRNA synthetase, Mitochondrial enzyme .

Asp-AMS Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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