The IC 50 s of MN58b for parental and Gemcitabine-resistant Suit2 007 cells are 3.14 μM and 0.77 μM, respectively.
It has a marked effect on colony formation at 1 μM, and growth is completely abolished at 5 μM in all the cell lines.
It induces apoptosis and this response correlates with CHKα expression.
Cell Viability Assay
| Cell Line: | SK-PC-1 , Suit2 008, IMIM-PC2, and RWP-1 cells |
| Concentration: | 1 μM, 5 μM |
| Incubation Time: | 72 hours |
| Result: | Inhibited ce lls growth. |
Apoptosis Analysis
| Cell Line: | SK-PC-1, Suit2 008, IMIM-PC2, and RWP -1 cells |
| Concentration: | 1 μM, 2 μM, 5 μM, 10 μM |
| Incubation Time: | 24 and 48 hours |
| Result: | Induced cell apoptosis. |
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