3-Acetoxy-α,α,α-trifluor-p-toluylsure

Bezeichnung:3-Acetoxy-α,α,α-trifluor-p-toluylsure

CAS-Nr322-79-2

Englisch Name:Triflusal

CBNumberCB9446472

SummenformelC10H7F3O4

Molgewicht248.16

MOL-Datei322-79-2.mol

Synonyma

3-Acetoxy-α,α,α-trifluor-p-toluylsure

3-Acetoxy-α,α,α-trifluor-p-toluylsure physikalisch-chemischer Eigenschaften

Schmelzpunkt	120-122° (upon slow heating); 110-112° (upon quick heating)
Siedepunkt	316.0±42.0 °C(Predicted)
Dichte	1.433±0.06 g/cm3(Predicted)
storage temp.	Sealed in dry,2-8°C
Löslichkeit	DMSO: >30mg/mL
pka	2.97±0.10(Predicted)
Aggregatzustand	powder
Farbe	white to off-white
maximale Wellenlänge (λmax)	297nm(H2O)(lit.)
Merck	14,9688
CAS Datenbank	322-79-2(CAS DataBase Reference)

Sicherheit

Kennzeichnung gefährlicher	Xn
R-Sätze:	22-36/37/38-43
S-Sätze:	26-36/37
WGK Germany	3
RTECS-Nr.	GP4250000
HS Code	2918.29.7500

Gefahreninformationscode (GHS)

Triflusal Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung
Triflusal is an antiplatelet agent structurally related to the salicylates, but it is not derived from ASA. Triflusal and its metabolite (3-hydroxy-4-triuoro-methylbenzoic acid or HTB) produce specic inhibition of platelet arachidonic acid metabolism (McNeely and Goa, 1998). A single 12-month open-label trial of Triflusal in 73 VaD patients (López-Pousa et al., 1997) showed fewer declines in MMSE scores in the active group compared with untreated subjects. More recently, Triflusal was used in patients with amnesic MCI; 257 patients were randomized to receive 900 mg of Triflusal or placebo for 18 months. Triflusal therapy was associated with a signicantly lower rate of conversion to dementia (Gómez-Isla et al., 2008).
Chemische Eigenschaften
White to Off-White Solid
Verwenden
An analog of Aspirin; inhibits platelet aggregation. Antithrombotic.
Verwenden
Antithrombotic;Cyclooxygenase inhibitor
Definition
ChEBI: 2-acetyloxy-4-(trifluoromethyl)benzoic acid is a member of salicylates, a carboxylic ester and a member of benzoic acids.
Mechanism of action
2-hydroxy-4-trifluoromethylbenzoic acid (HTB), the deacetylated metabolite of triflusal, retains significant antiplatelet activity. Triflusal is rapidly absorbed and metabolized. The area under the concentration–time curve for triflusal is 20.26 mg/L/hour after a 900-mg dose, whereas that for HTB is 42.27 mg/L/hour. Much of the pharmacokinetic data for triflusal activity is associated with HTB. The inhibition of COX, as measured by reduced production of thromboxane B2, is 25% after 2 hours and 85% after 7 days with triflusal, whereas the effects of aspirin on thromboxane B2 is more than 90% reduction after 2 hours and is maintained at this level after 7 days. It would appear that the presence of a 4-trifluoromethyl group also greatly enhances triflusal's ability to inhibit the activation of nuclear factor κB, which in turn regulates the expression of the mRNA of vascular cell adhesion molecule-1 needed for platelet aggregation. In addition, triflusal increases nitric oxide synthesis in neutrophils, which results in an increased vasodilatory potential. Finally, an additional site of action for triflusal/HTB is the inhibition of cAMP phosphodiesterase, leading to increased levels of cAMP. Elevated cAMP levels decrease platelet aggregation through decreased mobilization of calcium. Aspirin and salicylic acid do not significantly increase cAMP levels.
Clinical Use
Triflusal (2-acetoxy-4-trifluoromethyl benzoic acid) is an antiplatelet drug that despite its structural similarity to aspirin exhibits quite different pharmacological and pharmacokinetic properties.

Triflusal Upstream-Materialien And Downstream Produkte

3-Acetoxy-α,α,α-trifluor-p-toluylsure Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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