(+/-)-MUSCARINE CHLORIDE Struktur

(+/-)-MUSCARINE CHLORIDE

Bezeichnung:(+/-)-MUSCARINE CHLORIDE

CAS-Nr2936-25-6

Englisch Name:(+/-)-MUSCARINE CHLORIDE

CBNumberCB9427721

SummenformelC9H20ClNO2

Molgewicht209.71

MOL-Datei2936-25-6.mol

(+/-)-MUSCARINE CHLORIDE physikalisch-chemischer Eigenschaften

storage temp.	room temp
Löslichkeit	deionized water: ≥20mg/mL
Aggregatzustand	powder
Farbe	white
Wasserlöslichkeit	deionized water: ≥20mg/mL

Sicherheit

Kennzeichnung gefährlicher	Xn
R-Sätze:	22-36
S-Sätze:	26-36
RIDADR	1544
WGK Germany	3
HazardClass	6.1(a)
PackingGroup	II

Gefahreninformationscode (GHS)

(+/-)-MUSCARINE CHLORIDE Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R22:Gesundheitsschädlich beim Verschlucken.
R36:Reizt die Augen.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
Beschreibung
Muscarine is a natural alkaloid that is found in a number of wild mushrooms. Despite the fact that muscarine does not have any therapeutic value, it is of interest because of its expressed toxic properties, which made it one of the first systematically studied cholinomimetic substances. This compound was an underlying classification of cholinergic muscarinic receptors. The action of muscarine is similar to that of acetylcholine on peripheral autonomic effector organs, and atropine is an antagonist to it. Unlike acetylcholine, muscarine does not act on nicotinic receptors.
Verwenden
(+/-)-Muscarine Chloride is a muscarinic acteylcholine receptor agonist.
Biochem/physiol Actions
Muscarine is a potent agonist than acetylcholine and is not susceptible to degradation by cholinesterases. Muscarine administration results in muscle spasm especially in gut, bronchus and uterus.
Synthese
Muscarine, 2-methyl-3-hydroxy-5-(N,N,N-trimethylammonium) methylentetrahydrofuran chloride (13.1.14), was first isolated from the poisonous mushrooms Amanita muscaria. It can be synthesized in various ways from completely different substances [16¨C24], particularly from 2,5-dimethyl-3-carboxymethylflurane, which undergoes a Curtius reaction, i.e. successive reactions with hydrazine and further with nitrous acid in isopropyl alcohol, which forms the urethane (13.1.9), the acidic hydrolysis of which gives 2,5-dimethyl-2H-furane-3 (13.1.10). Allylic bromination of this gives 2- methyl-5-bromomethyl-2H-furanone-3 (13.1.11), which is reacted with dimethylamine, forming 2-methyl-5-dimethylaminomethyl-2H-fluranone-3 (13.1.12). Reducing this compound leads to formation of 2-methyl-3-hydroxy-5-dimethylaminomethyltetrahydroflurane (13.1.13), the reaction of which with methyl chloride gives muscarine (13.1.14) as a mixture of stereoisomers.

(+/-)-MUSCARINE CHLORIDE Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

2936-25-6, (+/-)-MUSCARINE CHLORIDE Verwandte Suche:

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