2-Bromophenylboronic acid

Bezeichnung:2-Bromophenylboronic acid

CAS-Nr244205-40-1

Englisch Name:2-Bromophenylboronic acid

CBNumberCB9421532

SummenformelC6H6BBrO2

Molgewicht200.83

MOL-Datei244205-40-1.mol

2-Bromophenylboronic acid physikalisch-chemischer Eigenschaften

Schmelzpunkt	113 °C(lit.)
Siedepunkt	329.2±44.0 °C(Predicted)
Dichte	1.67±0.1 g/cm3(Predicted)
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
Löslichkeit	Acetonitrile (Slightly), Chloroform (Slightly), DMSO (Slightly), Methanol (Sparingly)
Aggregatzustand	Powder
pka	8.25±0.58(Predicted)
Farbe	White to off-white
Wasserlöslichkeit	Soluble in methanol. Slightly soluble in water.
BRN	8542615
CAS Datenbank	244205-40-1(CAS DataBase Reference)

Sicherheit

Kennzeichnung gefährlicher	Xn,Xi
R-Sätze:	36/37/38-22
S-Sätze:	37/39-26
WGK Germany	3
HazardClass	IRRITANT
HS Code	29319090

Gefahreninformationscode (GHS)

2-Bromophenylboronic acid Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
R22:Gesundheitsschädlich beim Verschlucken.
S-Sätze Betriebsanweisung:
S37/39:Bei der Arbeit geeignete Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
Chemische Eigenschaften
White to off-white powder
Verwenden
2-Bromobenzeneboronic acid is a boronic acid derivative that is widely used in organic synthesis for carbon-carbon bond formation. In Suzuki coupling, aryl halides and boronic acid aryl or vinyl esters or boronic acids are coupled using Pd(PPh3)4.
Application
2-Bromophenylboronic Acid is used as an inhibitor of the hormone sensitive lipase.
Catalyzes the formation of amide bonds from amines and carboxylic acids.
Used to promote greener amidations of carboxylic acids and amines in catalytic amounts. This technology avoids the requirement of preactivation of the carboxylic acid or use of coupling reagents.
It is also an important intermediate for Organic Light-Emitting Diod ( OLED) .
synthetische
2-Bromophenylboronic acid synthesis: take 2-bromoaniline as raw material, synthesize the intermediate 1-Bromo-2-iodobenzene through diazotization and iodination, and then carry out magnesium iodide exchange with isopropylmagnesium bromide to synthesize o-bromophenylmagnesium bromide, It is then subjected to substitution reaction with trimethyl borate to synthesize methyl o-bromophenylboronic acid, and then hydrolyzed to synthesize 2-bromophenylboronic acid.

2-Bromophenylboronic acid Upstream-Materialien And Downstream Produkte

2-Bromophenylboronic acid Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

244205-40-1, 2-Bromophenylboronic acid Verwandte Suche:

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