Doxylaminhydrogensuccinat

Bezeichnung:Doxylaminhydrogensuccinat

CAS-Nr562-10-7

Englisch Name:Doxylamine succinate

CBNumberCB9416701

SummenformelC21H28N2O5

Molgewicht388.46

MOL-Datei562-10-7.mol

Synonyma

Doxylaminhydrogensuccinat

Doxylaminhydrogensuccinat physikalisch-chemischer Eigenschaften

Schmelzpunkt	95-98?C
Flammpunkt	9℃
storage temp.	2-8°C
Löslichkeit	Very soluble in water, freely soluble in ethanol (96 per cent).
Aggregatzustand	Solid
Farbe	White to Off-White
Stabilität	Stable, but may be light sensitive. Incompatible with strong oxidizing agents, acids, bases.
InChIKey	KBAUFVUYFNWQFM-UHFFFAOYSA-N
LogP	2.519 (est)
CAS Datenbank	562-10-7(CAS DataBase Reference)
IARC	3 (Vol. 79) 2001
EPA chemische Informationen	Doxylamine succinate (1:1) (562-10-7)

Sicherheit

Kennzeichnung gefährlicher	Xn,T,F
R-Sätze:	22-36/37/38-20/21/22-39/23/24/25-23/24/25-11
S-Sätze:	26-36/37-45-16-7
RIDADR	UN1230 - class 3 - PG 2 - Methanol, solution
WGK Germany	2
RTECS-Nr.	US9275000
HS Code	2933399090
Toxizität	LD50 in mice, rabbits (mg/kg): 470, 250 orally; 62, 49 i.v.; in mice, male rats, female rats (mg/kg): 460, 440, 445 s.c. (Brown, Werner)

Gefahreninformationscode (GHS)

Doxylamine succinate Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R22:Gesundheitsschädlich beim Verschlucken.
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36/37:Bei der Arbeit geeignete Schutzhandschuhe und Schutzkleidung tragen.
Chemische Eigenschaften
white to light cream powder
Verwenden
Doxylamine succinate salt has been used as a therapeutic drug to check developmental toxicity.
Verwenden
antihistaminic, hypnotic
Verwenden
H1 Histamine receptor antagonist. Antihistaminic; sedative; hypnotic.
Definition
ChEBI: Doxylamine succinate is an organic molecular entity.
Trademarks
Decapryn (Sanofi Aventis); Unisom (Pfizer).
Allgemeine Beschreibung
The acid succinate salt (bisuccinate)of doxylamine, 2-[ -[2-(dimethylamino)ethoxy]- -methylbenzyl]pyridine bisuccinate (Decapryn Succinate), isa white to creamy-white powder with a characteristic odor.It is soluble in water (1:1), alcohol (1:2), and chloroform(1:2). A 1% solution has a pH of about 5.Doxylamine succinate is comparable in potency todiphenhydramine. It is indicated for the relief of seasonalrhinitis symptoms, but is also used as a nighttime sedative.Concurrent use of alcohol and other CNS depressantsshould be avoided.
Allgemeine Beschreibung
White or creamy white powder. pH (1% aqueous solution) between 4.9 and 5.1.
Air & Water Reaktionen
Water soluble.
Health Hazard
SYMPTOMS: Symptoms of exposure to Doxylamine succinate may include drowsiness, excitability, nervousness, dizziness and sleeplessness.
Brandgefahr
Flash point data for Doxylamine succinate are not available. Doxylamine succinate is probably combustible.
Biochem/physiol Actions
H1 histamine receptor antagonist; hypnotic.Doxylamine suppresses histamine at the H1 receptor. It is associated with the short term management of insomnia and temporary relief of common cold symptoms. On the other hand, doxylamine intoxication is linked with rhabdomyolysis and secondary acute renal failure.Studies in mice show that doxylamine induces liver microsomal cytochrome P450 and other enzymes involved in thyroxine (T4) metabolism. In combination with pyridoxine hydrochloride, this drug is used to treat morning sickness.

Doxylaminhydrogensuccinat Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

562-10-7, Doxylamine succinate Verwandte Suche:

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