L-2-Hydroxy-2-phenylessigsure

Bezeichnung:L-2-Hydroxy-2-phenylessigsure

CAS-Nr611-71-2

Englisch Name:Mandelic acid

CBNumberCB9411418

SummenformelC8H8O3

Molgewicht152.15

MOL-Datei611-71-2.mol

Synonyma

L-2-Hydroxy-2-phenylessigsure

L-2-Hydroxy-2-phenylessigsure physikalisch-chemischer Eigenschaften

Schmelzpunkt	131-133 °C(lit.)
alpha	-150 º (c=2.5, H2O)
Siedepunkt	214.6°C (rough estimate)
Dichte	1.1677 (rough estimate)
Brechungsindex	-153.5 ° (C=1, H2O)
Flammpunkt	>190℃
storage temp.	Store below +30°C.
Löslichkeit	109.8g/l soluble
Aggregatzustand	Crystalline Powder, Crystals or Flakes
pka	3.37(at 25℃)
Farbe	White to slightly yellow-beige
PH	3.34(1 mM solution);2.75(10 mM solution);2.22(100 mM solution);
Optische Aktivität	[α]25/D 151°, c = 1 in ethanol
Wasserlöslichkeit	It is partly soluble in water, freely soluble in isopropyl and ethyl alcohol.
Sensitive	Light Sensitive
BRN	2691094
Stabilität	Stable, but light sensitive. Combustible. Incompatible with strong bases, strong oxidizing agents.
InChIKey	IWYDHOAUDWTVEP-SSDOTTSWSA-N
LogP	0.550 (est)
CAS Datenbank	611-71-2(CAS DataBase Reference)
EPA chemische Informationen	Benzeneacetic acid, .alpha.-hydroxy-, (.alpha.R)- (611-71-2)

Sicherheit

Kennzeichnung gefährlicher	Xi
R-Sätze:	41-36/37/38
S-Sätze:	22-24/25-36-26-39-37/39
WGK Germany	1
Hazard Note	Irritant/Light Sensitive
TSCA	Yes
HS Code	29181980
Toxizität	LD50 orally in Rabbit: 5000 mg/kg

Gefahreninformationscode (GHS)

Mandelic acid Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R41:Gefahr ernster Augenschäden.
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-Sätze Betriebsanweisung:
S22:Staub nicht einatmen.
S24/25:Berührung mit den Augen und der Haut vermeiden.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
Chemische Eigenschaften
white to light yellow crystal powde
Verwenden
(R)-(?)-Mandelic acid can be used:
- As a chiral acid in the separation of diastereomeric salts for the synthesis of chiral pyridoindole based building block.
- In the study of chiral acid selectivity of poly(3,4-ethylenedioxythiophene) (PEDOT) based chiral conducting?polymers.
Verwenden
(R)-(-)-Mandelic acid, is used as a antiseptic ingredient particularly against urinary tract infections.Mandelic acid and its derivatives are used to apply the dual activities as an antibacterial agent and as an antiaging agent. It is used as an intermediate for the synthesis of target molecules for other applications.
Verwenden
Antiseptic (urinary).
Definition
ChEBI: (R)-mandelic acid is the (R)-enantiomer of mandelic acid. It has a role as a human xenobiotic metabolite. It is a conjugate acid of a (R)-mandelate. It is an enantiomer of a (S)-mandelic acid.
Synthesis Reference(s)
The Journal of Organic Chemistry, 33, p. 2565, 1968 DOI: 10.1021/jo01270a105
Synthetic Communications, 18, p. 2141, 1988 DOI: 10.1080/00397918808068285
Allgemeine Beschreibung
(R)-(-)-Mandelic acid, a chiral resolving agent, is also used as a building block to synthesize pharmaceutical drugs such as penicillin and cephalosporin. It can be synthesized from (R,S)-mandelonitrile with high yield and enantioselectivity using nitrilase enzyme.
Flammability and Explosibility
Non flammable
läuterung methode
Purify the mandelic acids by recrystallisation from H2O, *C6H6 or CHCl3. [Roger J Chem Soc 2168 1932,Jamison & Turner J Chem Soc 611 1942.] They have solubilities in H2O of ca 11% at 25o. [Banks & Davies J Chem Soc 73 1938.] The S-benzylisothiuronium salts has m 180o (from H2O) and [] D 25 (+) and (-) 57o (c20, EtOH) [El Masri et al. Biochem J 68 199 1958]. [Beilstein 10 IV 564.]

Mandelic acid Upstream-Materialien And Downstream Produkte

L-2-Hydroxy-2-phenylessigsure Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

611-71-2, Mandelic acid Verwandte Suche:

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