BIS(2,4-DINITROPHENYL) CARBONATE

BIS(2,4-DINITROPHENYL) CARBONATE Chemische Eigenschaften,Einsatz,Produktion Methoden

• Beschreibung

  Bis(2,4-dinitrophenyl)carbonate is used in the preparation of azapeptides.

• Verwenden

  Peptide and azapeptide coupling reagent that functions by activating amines, forming derivatives suitable for condensation with N-protected amino acids; converts carboxylic acids to activated esters.

• Synthese

  Diphenyl carbonate (20 g) is added to a stirred mixture of conc HNO3 (100 mL) and conc H2SO4 (120 mL) at 50-55 °C over 1 h. The resulting suspension is stirred at 50 °C for 3 h, left at rt for 90 h and poured onto ice. The precipitate is washed with iced water and dried in vacuo over P2O5. This affords bis(2,4-dinitrophenyl) carbonate (31.2 g, 85%) which recrystallizes from hexane/benzene giving crystals, mp 144-146 °C.

• Vorsichtsmaßnahmen

  Store in a cool dry place to preclude contact with moisture; the hazardous and toxicological properties have not been investigated; may explode if heated rapidly

BIS(2,4-DINITROPHENYL) CARBONATE Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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