SC 19220

SC 19220 Chemische Eigenschaften,Einsatz,Produktion Methoden

• Verwenden

  SC 19220 is a selective EP1?receptor antagonist.

• Verwenden

  SC 19220 was used to study the role of prostaglandin E₂ in oxygen-glucose deprivation-induced neurotoxicity and preconditioning-induced neuroprotection in rat cortical cultures.

• Definition

  ChEBI: N'-acetyl-3-chloro-6H-benzo[b][1,4]benzoxazepine-5-carbohydrazide is an aromatic ether.

• Biologische Aktivität

  Selective EP 1 receptor antagonist (IC 50 = 6.7 μ M for inhibition of [ 3 H]-PGE 2 binding to EP 1 transfected COS cells).

• Biochem/physiol Actions

  SC 19220 is a competitive antagonist of prostaglandin E receptors. It competes with PGE2 in regulating vesicourethral motility and increases the bladder capacity of rats. It inhibits the contraction of smooth muscles in response to prostaglandins E2 and F2α. SC 19220 also inhibits the formation of osteoclasts induced by vitamin D3, parathyroid hormone, IL-11 and IL-6.

• Lager

  Store at RT

SC 19220 Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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