E3 ligase Ligand-Linker Conjugates 13

E3 ligase Ligand-Linker Conjugates 13 Chemische Eigenschaften,Einsatz,Produktion Methoden

• Verwenden

  Protein degrader builiding block (S,R,S)-AHPC-PEG2-azide enables the synthesis of molecules for targeted protein degradation and PROTAC (proteolysis-targeting chimeras) technology. This conjugate contains a von Hippel-Lindau (VHL)-recruiting ligand and a PEGylated crosslinker with pendant azide for click chemistry with a target ligand. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and PROTAC, many analogs are prepared to screen for optimal target degradation. When used with other protein degrader building blocks with a pendant azide group, parallel synthesis can be used to more quickly generate PROTAC libraries that feature variation in crosslinker length, composition, and E3 ligase ligand.

• reaction suitability

  reaction type: click chemistry
  reagent type: ligand-linker conjugate

E3 ligase Ligand-Linker Conjugates 13 Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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