PROPIONYL-L-CARNITINE HYDROCHLORIDE Struktur

PROPIONYL-L-CARNITINE HYDROCHLORIDE

Bezeichnung:PROPIONYL-L-CARNITINE HYDROCHLORIDE

CAS-Nr20064-19-1

Englisch Name:PROPIONYL-L-CARNITINE HYDROCHLORIDE

CBNumberCB9338050

SummenformelC10H19NO4

Molgewicht217.27

MOL-Datei20064-19-1.mol

PROPIONYL-L-CARNITINE HYDROCHLORIDE physikalisch-chemischer Eigenschaften

storage temp.	2-8°C
Löslichkeit	Chloroform (Slightly), Methanol (Very Slightly), Water (Slightly)
Aggregatzustand	Semi-Solid to Solid
Farbe	Colourless to Off-White
Optische Aktivität	[α]/D -23±3°, c = 1 in H2O
Stabilität	Hygroscopic

PROPIONYL-L-CARNITINE HYDROCHLORIDE Chemische Eigenschaften,Einsatz,Produktion Methoden

Verwenden
Propionyl-L-carnitine was identified in the drinking water in rats.
Verwenden
L-Propionyl carnitine has been shown to improve the heart mechanical recovery and other metabolic parameters after ischemia-reperfusion
Verwenden
Propionyl-L-carnitine has been used as a standard in liquid chromatography-tandem mass spectrometry (LC-MS/MS).
Definition
ChEBI: O-propanoyl-L-carnitine is an optically active O-acylcarnitine compound having propanoyl as the acyl substituent and (R)-configuration at the 3-position. It has a role as a peripheral nervous system drug. It is an O-propanoylcarnitine and a saturated fatty acyl-L-carnitine.
Allgemeine Beschreibung
Propionyl-L-carnitine (PLC), a natural odd-carbon-number, endogenous ester of L-carnitine, is found to be present in humans and animals as a minor component compared to L-carnitine (LC) and acetyl-L-carnitine (ALC). It acts as a carrier of long chain acyl groups from activated fatty acids across the inner mitochondrial membrane into the mitochondrial matrix where they undergo β-oxidation to acetyl CoA to obtain usable energy via the citric acid cycle.
Biochem/physiol Actions
Propionyl-L-carnitine (PLC) plays a key role in lipid and carbohydrate metabolism. It provides substrates to the ischemic muscle for energy production and ATP generation. PLC has the potential to treat severe peripheral arterial disease and chronic heart failure. It is present in high abundance in the urine of patients with methylmalonyl-CoA mutase (MUT) deficiency, together with methylmalonic acid. MUT is a mitochondrial enzyme that catalyzes the isomerization of methylmalonyl-CoA to succinyl-CoA.

PROPIONYL-L-CARNITINE HYDROCHLORIDE Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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