Acetaminosalol

Bezeichnung:Acetaminosalol

CAS-Nr118-57-0

Englisch Name:2-HYDROXYBENZOIC ACID 4-(ACETYLAMINO)PHENYL ESTER

CBNumberCB9322358

SummenformelC15H13NO4

Molgewicht271.27

MOL-Datei118-57-0.mol

Synonyma

Acetaminosalol

Acetaminosalol physikalisch-chemischer Eigenschaften

Schmelzpunkt	187°
Stabilität	Stable. Incompatible with strong oxidizing agents.
LogP	2.562 (est)

Gefahreninformationscode (GHS)

2-HYDROXYBENZOIC ACID 4-(ACETYLAMINO)PHENYL ESTER Chemische Eigenschaften,Einsatz,Produktion Methoden

Chemische Eigenschaften
solid
Originator
Acetaminosal ,ZYF Pharm Chemical
Verwenden
Analgesic; antipyretic.
Definition
ChEBI: Acetaminosalol is a carbonyl compound.
Manufacturing Process
2 Methods of producing of acetyl salicylic acid ester of N-acetyl-paminophenol:
1. 65.0 g of N-acetyl-p-aminophenol were slurried with 400 ml of water and cooled to 10°C. 125 ml of 20% sodium hydroxide were slowly added to the mixture with stirring, the temperature being maintained 10°-15°C. To the solution obtained, 75.0 g of acetyl salicylic chloride were added with vigorous stirring over a period of 0.5 h, the solution being maintained at a temperature of about 10°C. Towards the end of the reaction the pH was checked and adjusted to greater than 10 by the addition of a small amount of 20% sodium hydroxide. After all the acid chloride had been added, vigorous stirring was continued for 0.5 h during which time the crude product separated out. The acetyl salicylic acid ester of N-acetyl-p-aminophenol was filtered off, washed thoroughly with water and recrystallised from ethanol.
2. 65.0 g of sodium N-acetyl-p-aminophenol were slurried with 500.0 g of dry benzene and 80.0 g of acetyl salicylic chloride added. The mixture was heated under reflux for 4 h and filtered hot. The excess benzene was removed under vacuum and the crude acetyl salicylic acid ester of N-acetyl-p-aminophenol crystallized from ethanol.
Trademarks
Acephen (G & W); Infants’ Feverall (Actavis); Injectapap (Ortho-McNeil); Neopap (Polymedica); Tylenol (McNeil).
Therapeutic Function
Analgesic, Antineuralgic, Antirheumatic, Antipyretic

2-HYDROXYBENZOIC ACID 4-(ACETYLAMINO)PHENYL ESTER Upstream-Materialien And Downstream Produkte

Acetaminosalol Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

118-57-0, 2-HYDROXYBENZOIC ACID 4-(ACETYLAMINO)PHENYL ESTER Verwandte Suche:

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