Aminooxy-PEG2-azide

Aminooxy-PEG2-azide Chemische Eigenschaften,Einsatz,Produktion Methoden

• Beschreibung

  Aminooxy-PEG2-azide contain an azide and an aminooxy group. The aminooxy group reacts with an aldehyde or ketone group to form a oxime linkage. The azide group enables Click Chemistry. Aminooxy compounds are very reactive and sensitive; they cannot be stored for long term. Immediate use (within 1 week) is highly recommended.

• Biologische Aktivität

  Aminooxy-PEG2-azide is a PROTAC linker belonging to the PEG class, which can be used to synthesize PROTAC molecules.It is also a non-cleavable ADC linker containing 2-unit PEG, which can be used to synthesize antibody drug conjugates (ADCs).

• in vitro

  PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
  ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.

• target

  PEGs	Non-cleavable

Aminooxy-PEG2-azide Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global(25)Suppliers