IMR-1A Struktur

IMR-1A

Bezeichnung:IMR-1A

CAS-Nr331862-41-0

Englisch Name:IMR-1A

CBNumberCB93133188

SummenformelC13H11NO5S2

Molgewicht325.36

MOL-Datei331862-41-0.mol

IMR-1A physikalisch-chemischer Eigenschaften

Dichte	1.55±0.1 g/cm3(Predicted)
storage temp.	under inert gas (nitrogen or Argon) at 2-8°C
Löslichkeit	DMSO:4.0(Max Conc. mg/mL);12.29(Max Conc. mM) Water:1.0(Max Conc. mg/mL);3.07(Max Conc. mM)
pka	3.10±0.10(Predicted)
Aggregatzustand	Solid
Farbe	Light yellow to yellow

Gefahreninformationscode (GHS)

IMR-1A Chemische Eigenschaften,Einsatz,Produktion Methoden

Biologische Aktivität
IMR-1A is a potent inhibitor of Notch with IC50 of 0.5 μM and Kd of 2.9 μM. It has antitumor activity.

in vivo

IMR-1A (2 mg/kg (iv) and 100 mg/kg (ip)) exhibits low systematic plasma clearance (CL = 7 mL/min/kg) with terminal elimination half-life (T1/ 2) of 2.22 h following a single iv administration. The normal liver blood flow in mice is 90 mL/min/kg and the Vss (volume of distribution) is ~4-fold. Plasma concentrations is quantifiable up to 24 h with Tmax of 0.50 h after ip administration.

< td class="col1 fwb"> Administration:

Animal Model:	Male C57 BL/6 mice
Dosage:	2 mg/kg (iv) and 100 mg/kg (ip)
Iv and ip
Result:	Exhibited low systematic plasma clearance (CL = 7 mL/min/kg) with terminal elimination half-life (T1/2) of 2.22 h following a single iv administration and plasma concentrations is quantifiable up to 24 h with Tmax of 0.50 h after ip administration.

target

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IMR-1A Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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Target	Value
Notch (Cell-free assay)	0.5 μM
Notch (Cell-free assay)	2.9 μM(Kd)