TCO-PEG4-NHS ester Struktur

TCO-PEG4-NHS ester

Bezeichnung:TCO-PEG4-NHS ester

Englisch Name:TCO-PEG4-NHS ester

CBNumberCB93062671

SummenformelC24H38N2O10

Molgewicht514.57

TCO-PEG4-NHS ester physikalisch-chemischer Eigenschaften

Dichte	1.23±0.1 g/cm3(Predicted)
Löslichkeit	Soluble in DMSO, DCM, DMF
pka	11.95±0.46(Predicted)
Aggregatzustand	Oil
Farbe	Colorless to light yellow
InChI	InChI=1S/C24H38N2O10/c27-21-8-9-22(28)26(21)36-23(29)10-12-31-14-16-33-18-19-34-17-15-32-13-11-25-24(30)35-20-6-4-2-1-3-5-7-20/h1-2,20H,3-19H2,(H,25,30)/b2-1-
InChIKey	ZKPMRASGLDBKPF-UPHRSURJSA-N
SMILES	C(OC1CCCC=CCC1)(=O)NCCOCCOCCOCCOCCC(ON1C(=O)CCC1=O)=O \|c:6\|

Gefahreninformationscode (GHS)

Beschreibung
TCO-PEG4-NHS Ester is a click chemistry crosslinker. This reagent can be used to label antibodies, proteins and other primary amine containing molecule. The hydrophilic PEG spacer increases water-solubility and decreases steric hindrance during ligation. TCO enable fast click chemistry under mild condition
Biologische Aktivität
TCO-PEG4-NHS ester is a PROTAC linker and belongs to the PEG class,it can be used to synthesize a series of PROTAC molecules.It is a cleavable ADC linker for the synthesis of antibody drug conjugates (ADCs).
in vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.

target

Cleavable

PEGs