Bromo-PEG2-azide

Bromo-PEG2-azide Chemische Eigenschaften,Einsatz,Produktion Methoden

• Beschreibung

  Bromo-PEG2-azide is a heterobifunctional crosslinking reagent.. The azide group can react with alkyne, BCN, DBCO via Click Chemistry. The bromide (Br) is a good leaving group for nucleophilic substitution.

• Biologische Aktivität

  Bromo-PEG2-C2-azide is a non-degradable ADC linker for the synthesis of antibody drug conjugates (ADCs),it is also a PEG-based PROTAC linker that can be used for PROTAC synthesis.

• in vitro

  ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
  PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

• target

  Non-cleavable < span>

  PEGs

Bromo-PEG2-azide Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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