Ald-PEG3-Azide Struktur

Ald-PEG3-Azide

Bezeichnung:Ald-PEG3-Azide

Englisch Name:Ald-PEG3-Azide

CBNumberCB93062297

SummenformelC8H15N3O4

Molgewicht217.23

Ald-PEG3-Azide physikalisch-chemischer Eigenschaften

Löslichkeit

Soluble in Water, DMSO, DMF, DCM

Ald-PEG3-Azide Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung
Ald-CH2-PEG3-azide is a click chemistry PEG linker. Aldehyde groups are likely to undergo nucleophile substitution, reduction and oxidation reactions. The azideN3 enable Click Chemistry reactions with alkynes, DBCO and BCN to form triazole groups. PEG3 spacer increases the water solubility of the compound.
Biologische Aktivität
Ald-CH2-PEG3-azide is a cleavable 3-unit PEG-containing ADC linker that can be used to synthesize antibody drug conjugates (ADCs),it is a PROTAC linker belonging to the PEG class and can be used to synthesize PROTAC molecules.
in vitro

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.

target

Cleavable

PEGs