Nesfatin-1(nesf-1), the 82 aa peptide processed from
nucleobindin 2 (NUCB2), is involved in the regulation of
feeding behavior, gastrointestinal motility, glucose homeostasis, anxiety and depression, cardiovascular functions, thermoregulation, and reproductive functions. Nesf-1 was discovered in 2006 as a potent anorexigenic
peptide in the rat hypothalamus. The 82 aa peptide is
cleaved from its precursor protein NUCB2. In addition
to birds and amphibians, NUCB2 was identified in Cyprinidae, including goldfish and zebrafish. NUCB2 is
widely distributed in the central nervous system (CNS)
and peripheral tissues of vertebrates.
