CGP52421

CGP52421 Chemische Eigenschaften,Einsatz,Produktion Methoden

• Verwenden

  3-Hydroxy Midostaurin-d5 is the deuterium labelled 3-Hydroxy Midostaurin (H939985(M)). 3-Hydroxy Midostaurin is a metabolite of Midostaurin (M343760), a compound shown to possess antiproliferative characteristics via inhibition of protein kinase C, kinase insert domain receptor, and c-kit.

• Biologische Aktivität

  3-Hydroxy Midostaurin (CGP 52421), a metabolite of PKC412, potently inhibits FMS-like tyrosine kinase 3 (FLT3) autophosphorylation with IC50s of 132 nM and 9.8 μM in culture medium and plasma, respectively. Compared to PKC412, 3-Hydroxy Midostaurin is less selective but more cytotoxic.

• in vitro

  CGP52421 (200, 400, 600, 800, 1000 nM) is more cytotoxic than PKC412 over the dose range 100 to 500 nM.

• target

  IC50: 132 nM (FLT3 in culture medium) and 9.8 μM (FLT3 in plasma)

CGP52421 Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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