ReModelin Struktur

ReModelin

Bezeichnung:ReModelin

CAS-Nr949912-58-7

Englisch Name:ReModelin

CBNumberCB92729373

SummenformelC15H14N4S

Molgewicht282.36

MOL-Datei949912-58-7.mol

ReModelin physikalisch-chemischer Eigenschaften

Siedepunkt	498.9±47.0 °C(Predicted)
Dichte	1.31±0.1 g/cm3(Predicted)
storage temp.	2-8°C
Löslichkeit	DMSO: soluble20mg/mL, clear
Aggregatzustand	powder
pka	14.40±0.20(Predicted)
Farbe	white to beige
Stabilität	Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.

Sicherheit

Kennzeichnung gefährlicher	Xn
R-Sätze:	22
WGK Germany	3

Gefahreninformationscode (GHS)

ReModelin Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung
Progeria is a genetic disorder that results in the appearance of premature aging. Genetically, progeria is characterized by a mutation in lamin A, which results in misshapen cell nuclei and DNA damage. Remodelin is a 2-thiazolylhydrazone derivative that, at 10 μM, improves nuclear architecture, chromatin organization, and survival of both cells lacking lamin A and cells from patients with progeria. Remodelin is an inhibitor of N-acetyltransferase 10 (NAT10), which acetylates both histones and microtubules. Mutation of NAT10 mimics the effects of remodelin on nuclear morphology, suggesting that these effects of remodelin require NAT10. Remodelin also has cytotoxic effects against some species of the fungus Candida.
Verwenden
Remodelin improves nuclear architecture, chromatin organization, and fitness of both human lamin A/C-depleted cells and Hutchinson-Gilford progeria syndrome (HGPS)-derived patient cells. N-acetyltransferase 10 (NAT10) inhibitor.
Lager
Store at +4°C
Einzelnachweise
1) Larrieu?et al.?(2014),?Chemical Inhibition of NAT10 Corrects Defects of Laminopathic Cells; Science,?344?527 2) Larrieu?et al.?(2018),?Inhibition of the Acetyltransferase NAT10 Normalizes Progeric and Aging Cells by Rebalancing the Transportin-1 Nuclear Import Pathway; Sci. Signal.,?11?eaar5401 3) Balmus?et al.?(2018),?Targeting of NAT10 Enhances Healthspan in a Mouse Model of Human Accelerated Aging Syndrome; Nat. Commun., 9?1700 4) Cobb?et al. (2016),?Prelamin A impairs 53BP1 nuclear entry by mislocalizing NUP153 and disrupting the Ran gradient; Aging Cell,?15?1039 5) Ma?et al.?(2016),?Up regulation of NAT10 promotes metastasis of hepatocellular carcinoma cells through epithelial-to-mesenchymal transition; Am. J. Transl. Res.,?8?4215

ReModelin Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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