p-Hydroxybenzamid

Bezeichnung:p-Hydroxybenzamid

CAS-Nr619-57-8

Englisch Name:4-Hydroxybenzamide

CBNumberCB9271791

SummenformelC7H7NO2

Molgewicht137.14

MOL-Datei619-57-8.mol

Synonyma

p-Hydroxybenzamid

p-Hydroxybenzamid physikalisch-chemischer Eigenschaften

Schmelzpunkt	161-162 °C (lit.)
Siedepunkt	345.3±25.0 °C(Predicted)
Dichte	1.286±0.06 g/cm3(Predicted)
storage temp.	Sealed in dry,Room Temperature
Aggregatzustand	powder to crystal
pka	8.60±0.13(Predicted)
Farbe	White to Light yellow to Dark green
BRN	1906921
InChI	InChI=1S/C7H7NO2/c8-7(10)5-1-3-6(9)4-2-5/h1-4,9H,(H2,8,10)
InChIKey	QXSAKPUBHTZHKW-UHFFFAOYSA-N
SMILES	C(N)(=O)C1=CC=C(O)C=C1
CAS Datenbank	619-57-8(CAS DataBase Reference)

Sicherheit

Kennzeichnung gefährlicher	Xi
R-Sätze:	36/37/38
S-Sätze:	26-37/39-36
WGK Germany	3
HazardClass	IRRITANT
HS Code	29242990

Gefahreninformationscode (GHS)

4-Hydroxybenzamide Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S37/39:Bei der Arbeit geeignete Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
Chemische Eigenschaften
White to off-white crystalline powder
Verwenden
4-Hydroxybenzamide was used in the synthesis of balanol, a potent protein kinase C (PKC) inhibitor.
Verwenden
4-Hydroxybenzamide is a secondary metabolite from marine sponge Phakellia fusca.
Definition
4-Hydroxybenzamide (4HBM) is an important biological active compound that has the presence of various biological activities such as antimycobacterial, antifungal, antimicrobial, herbicidal, and antioxidant. The benzamide derivatives are also used in medical, pharmaceutical, and therapeutic applications because of their anti-inflammatory, antibacterial, and antifungal activities. The amine and carboxylic acids are important functional groups of present molecules. These are mainly utilized in the field of chemical industry. The cocrystallization of itraconazole (a very slightly soluble triazole antifungal drug) with 4-hydroxybenzamide (4OHBZA) can potentially increase the drug solubility at pH1.2 and 37 °C by 64 times[1-2].
Einzelnachweise
[1] Ramesh P, et al. Theoretical and experimental spectroscopic studies of monomeric and dimeric structures of 4-hydroxybenzamide International Journal of Pharmaceutics. Journal of Molecular Structure, 2020; 1206: 127742.
[2] Vasilev N, et al. Novel cocrystals of itraconazole: Insights from phase diagrams, formation thermodynamics and solubility. International Journal of Pharmaceutics, 2021; 599: 120441.
Synthesis Reference(s)
Tetrahedron Letters, 19, p. 5183, 1978 DOI: 10.1016/S0040-4039(01)85844-5
Allgemeine Beschreibung
The standard molar enthalpy of formation of 4-hydroxybenzamide was studied by micro- or macrocombustion calorimetry.
Source
4-Hydroxybenzamide is a natural product found in Oxytropis falcata, Houttuynia cordata, and Streptomyces tendae with data available.

4-Hydroxybenzamide Upstream-Materialien And Downstream Produkte

p-Hydroxybenzamid Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

619-57-8, 4-Hydroxybenzamide Verwandte Suche:

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