Magnolol

Bezeichnung:Magnolol

CAS-Nr528-43-8

Englisch Name:Magnolol

CBNumberCB9265352

SummenformelC18H18O2

Molgewicht266.33

MOL-Datei528-43-8.mol

Magnolol physikalisch-chemischer Eigenschaften

Schmelzpunkt	101.5-102°
Siedepunkt	180°C/1mmHg(lit.)
Dichte	1.107±0.06 g/cm3(Predicted)
FEMA	4559 \| MAGNOLOL
storage temp.	Sealed in dry,2-8°C
Löslichkeit	ethanol: soluble1mg/mL
pka	9.49±0.43(Predicted)
Farbe	White to Almost white
Geruch (Odor)	bitter
maximale Wellenlänge (λmax)	292nm(EtOH)(lit.)
JECFA Number	2023
Merck	14,5697
Stabilität	Light Sensitive
LogP	4.502 (est)
CAS Datenbank	528-43-8(CAS DataBase Reference)

Sicherheit

Kennzeichnung gefährlicher	N
R-Sätze:	37/38-41-51/53
S-Sätze:	26-39-61
RIDADR	UN 3077
WGK Germany	3
RTECS-Nr.	DV5105500
HS Code	29072990
Giftige Stoffe Daten	528-43-8(Hazardous Substances Data)
Toxizität	LD50 orl-mus: 2200 mg/kg BRXXAA #5135746

Gefahreninformationscode (GHS)

Magnolol Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R37/38:Reizt die Atmungsorgane und die Haut.
R41:Gefahr ernster Augenschäden.
R51/53:Giftig für Wasserorganismen, kann in Gewässern längerfristig schädliche Wirkungen haben.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S39:Schutzbrille/Gesichtsschutz tragen.
S61:Freisetzung in die Umwelt vermeiden. Besondere Anweisungen einholen/Sicherheitsdatenblatt zu Rate ziehen.
Beschreibung
Magnolol is a bioactive compound isolated from the bark of M. officinalis that has been used in Asian traditional medicine for the treatment of anxiety, sleep disorders, and allergic diseases. Magnolol can activate cannabinoid (CB) receptors, behaving as a partial agonist with selectivity for the peripheral CB₂ subtype (EC₅₀ = 3.28 μM; K_i = 1.44 μM) versus central CB₁ (EC₅₀ = 18.3 μM; K_i = 3.15 μM).
Chemische Eigenschaften
White or off-white powder
Verwenden
Magnolol is the bioactive phytochemicals found in Magnolia officinalis (1). Magnolol has been used to treat anxiety, cough, headache and allergies (2). It also inhibits tumor necrosis factor-a-*induced ICAM-1 expression in human lung epithelial cells.
Definition
ChEBI: Magnolol is a member of biphenyls.
Hazard
Moderately toxic by ingestion.
Biologische Aktivität
Magnolol, a natural lignan isolated from the stem bark of Magnolia officinalis, is a dual agonist of both RXRα and PPARγ, with EC50 values of 10.4 μM and 17.7 μM, respectively.
Mechanism of action
Magnolol (5,5’-diallyl-2,2’-dihydroxybiphenyl) is a polyphenolic binaphthalene compound and a structural isomer of honokiol. Both magnolol and honokiol are isolated from the stem bark of a traditional Chinese herbal medicine Magnolia officinalis, which has been used for management of nervous disturbance, abdominal distention or disorders, gastrointestinal food stagnancy, and coughing and dyspnea. Magnolol has showed a wide spectrum of beneficial activities, including anti-inflammation, antimicroorganism, antioxidation, antiangiogenesis, anticancer, neuroprotection, cardiovascular protection, and lipolysis activities.
Sicherheitsprofil
Moderately toxic by ingestion.When heated to decomposition it emits acrid smoke andirritating vapors.
in vitro
Magnolol is a bioactive lignin found in the bark of the Houpu magnolia (Magnolia officinalis) which shows antifungal properties. Magnolol preferentially increases (3)H-muscimol binding to hippocampus compared to cortex and cerebellum in vitro. Magnolol has a more potent enhancing effect on GABAA receptor alpha2 subunit. Magnolol shows significant inhibitory activities against Trichophyton mentagrophytes, Microsporium gypseum, Epidermophyton floccosum, Aspergillus niger, Cryptococcus neoformans, and Candida albicans with minimum inhibitory concentrations (MIC) in a range of 25-100 μg/ml.
in vivo
Magnolol (5-15 mg/kg, p.o.) significantly attenuates the phenotypic severity of dextran sulfate sodium (DSS)-induced colitis in mice. Magnolol (10, 15 mg/kg, p.o.) attenuates histopathological changes and myeloperoxidase activity in the colon of DSS-treated mice, decreases DSS-induced high levels of proinflammatory cytokines TNF-α, IL-1β and IL-6 in the colonic tissues. Magnolol (10 mg/kg, p.o.) also reverses abnormality of serum metabolome, and regulates tryptophan metabolic pathway in mice.

Magnolol Upstream-Materialien And Downstream Produkte

Magnolol Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

528-43-8, Magnolol Verwandte Suche:

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