NSC-348884 Struktur

NSC-348884

Bezeichnung:NSC-348884

CAS-Nr81624-55-7

Englisch Name:NSC-348884

CBNumberCB92582798

SummenformelC38H40N10

Molgewicht636.79

MOL-Datei81624-55-7.mol

NSC-348884 physikalisch-chemischer Eigenschaften

Siedepunkt	1001.7±65.0 °C(Predicted)
Dichte	1.347
storage temp.	under inert gas (nitrogen or Argon) at 2-8°C
Löslichkeit	≥63.7 mg/mL in DMSO; insoluble in EtOH; insoluble in H2O
Aggregatzustand	solid
pka	11.61±0.10(Predicted)
Farbe	Light yellow to yellow

NSC-348884 Chemische Eigenschaften,Einsatz,Produktion Methoden

Verwenden
NSC348884 is a biochemical which inhibitss NPM oligomer formation, upregulates p53 and induces apoptosis.
Biologische Aktivität
nsc348884 is a nucleophosmin inhibitor.nucleophosmin is identified as a multifunctional nucleolar phosphoprotein, which is dysregulated in human malignancies resulting in anti-apoptosis and differentiation inhibition.
in vitro
nsc348884, which was identified as a putative nucleophosmin small molecular inhibitor, was found to be able to disrupt a hydrophobic pocket that was required for oligomerization, and nsc348884 could also inhibit the cell proliferation in distinct cancer cell lines and disrupt nucleophosmin oligomer formation. moreover, the treatment of several cancer cell types with nsc348884 could dose-dependently upregulate p53 and also induce apoptosis that correlated with h2ax phosphorylation, poly(adp-ribose) polymerase cleavage as well as annexin v. furthermore, nsc348884 could also synergize doxorubicin cytotoxicity on the viability of cancer cells [1].
in vivo
previous study showed that the in-vivo intravasation and invasion could be significantly inhibited after the injection of nsc348884 into the tumor-bearing mice. in addition, there was no significant difference in overall cell death that was observed by histology in the treated tumors with the 4-hour brief treatments, indicating that the inhibition seen was specific to migration [2].
IC 50
1.7-4.0 μm for tested cancer cell lines
Einzelnachweise
[1] qi w,shakalya k,stejskal a,goldman a,beeck s,cooke l,mahadevan d. nsc348884, a nucleophosmin inhibitor disrupts oligomer formation and induces apoptosis in human cancer cells. oncogene.2008 jul 10;27(30):4210-20.
[2] patsialou a,wang y,lin j,whitney k,goswami s,kenny pa,condeelis js. selective gene-expression profiling of migratory tumor cells in vivo predicts clinical outcome in breast cancer patients. breast cancer res.2012 oct 31;14(5):r139.

NSC-348884 Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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